Short-Term Exposure to High Sucrose Levels near Weaning Has a Similar Long-Lasting Effect on Hypertension as a Long-Term Exposure in Rats

被引:15
作者
Villegas-Romero, Mariana [1 ]
Castrejon-Tellez, Vicente [1 ]
Perez-Torres, Israel [2 ]
Esther Rubio-Ruiz, Maria [1 ]
Carreon-Torres, Elizabeth [3 ]
Diaz-Diaz, Eulises [4 ]
del Valle-Mondragon, Leonardo [5 ]
Guarner-Lans, Veronica [1 ]
机构
[1] Inst Nacl Cardiol Ignacio Chavez, Dept Physiol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico
[2] Inst Nacl Cardiol Ignacio Chavez, Dept Pathol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico
[3] Inst Nacl Cardiol Ignacio Chavez, Dept Mol Biol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico
[4] Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Reprod Biol, Vasco de Quiroga 15,Secc 16, Mexico City 14000, DF, Mexico
[5] Inst Nacl Cardiol Ignacio Chavez, Dept Pharmacol, Juan Badiano 1,Secc 16, Mexico City 14080, DF, Mexico
关键词
critical window; hypertension; sucrose; endothelial nitric oxide synthase; oxidative stress; fatty acids; NITRIC-OXIDE SYNTHASE; LOW-DENSITY-LIPOPROTEIN; ADULT-BLOOD PRESSURE; OXIDATIVE STRESS; SUPEROXIDE-DISMUTASE; ENDOTHELIAL FUNCTION; VASCULAR REACTIVITY; PROTEIN-SYNTHESIS; HIGH-CARBOHYDRATE; ARACHIDONIC-ACID;
D O I
10.3390/nu10060728
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Adverse conditions during early developmental stages permanently modify the metabolic function of organisms through epigenetic changes. Exposure to high sugar diets during gestation and/or lactation affects susceptibility to metabolic syndrome or hypertension in adulthood. The effect of a high sugar diet for shorter time lapses remains unclear. Here we studied the effect of short-term sucrose ingestion near weaning (postnatal days 12 and 28) (STS) and its effect after long-term ingestion, for a period of seven months (LTS) in rats. Rats receiving sucrose for seven months develop metabolic syndrome (MS). The mechanisms underlying hypertension in this model and those that underlie the effects of short-term exposure have not been studied. We explore NO and endothelin-1 concentration, endothelial nitric oxide synthase (eNOS) expression, fatty acid participation and the involvement of oxidative stress (OS) after LTS and STS. Blood pressure increased to similar levels in adult rats that received sucrose during short- and long-term glucose exposure. The endothelin-1 concentration increased only in LTS rats. eNOS and SOD2 expression determined by Western blot and total antioxidant capacity were diminished in both groups. Saturated fatty acids and arachidonic acid were only decreased in LTS rats. In conclusion, a high-sugar diet during STS increases the hypertension predisposition in adulthood to as high a level as LTS, and the mechanisms involved have similarities (participation of OS and eNOS and SOD expression) and differences (fatty acids and arachidonic acid only participate in LTS and an elevated level of endothelin-1 was only found in LTS) in both conditions. Changes in the diet during short exposure times in early developmental stages have long-lasting effects in determining hypertension susceptibility.
引用
收藏
页数:20
相关论文
共 99 条
[1]   A dietary intervention (high carbohydrate) during the neonatal period causes islet dysfunction in rats [J].
Aalinkeel, R ;
Srinivasan, M ;
Kalhan, SC ;
Laychock, SG ;
Patel, MS .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1999, 277 (06) :E1061-E1069
[2]   Restructuring of Pancreatic Islets and Insulin Secretion in a Postnatal Critical Window [J].
Aguayo-Mazzucato, Cristina ;
Sanchez-Soto, Carmen ;
Godinez-Puig, Victoria ;
Gutierrez-Ospina, Gabriel ;
Hiriart, Marcia .
PLOS ONE, 2006, 1 (01)
[3]   Modified Lipid Extraction Methods for Deep Subsurface Shale [J].
Akondi, Rawlings N. ;
Trexler, Ryan V. ;
Pfiffner, Susan M. ;
Mouser, Paula J. ;
Sharma, Shikha .
FRONTIERS IN MICROBIOLOGY, 2017, 8
[4]   Placental insufficiency leads to development of hypertension in growth-restricted offspring [J].
Alexander, BT .
HYPERTENSION, 2003, 41 (03) :457-462
[5]  
Banos G, 1997, AM J HYPERTENS, V10, P379
[6]   Effect of 8-isoprostaglandin F2α on the newborn rat pulmonary arterial muscle and endothelium [J].
Belik, J ;
Jankov, RP ;
Pan, J ;
Yi, M ;
Pace-Asciak, CR ;
Tanswell, AK .
JOURNAL OF APPLIED PHYSIOLOGY, 2003, 95 (05) :1979-1985
[7]   The ferric reducing ability of plasma (FRAP) as a measure of ''antioxidant power'': The FRAP assay [J].
Benzie, IFF ;
Strain, JJ .
ANALYTICAL BIOCHEMISTRY, 1996, 239 (01) :70-76
[8]   RISK-FACTORS IN EARLY LIFE AS PREDICTORS OF ADULT HEART-DISEASE - THE BOGALUSA HEART-STUDY [J].
BERENSON, GS ;
SRINIVASAN, SR ;
HUNTER, SM ;
NICKLAS, TA ;
FREEDMAN, DS ;
SHEAR, CL ;
WEBBER, LS .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1989, 298 (03) :141-151
[9]   MARKED REDUCTION OF FREE-RADICAL GENERATION AND CONTRACTILE DYSFUNCTION BY ANTIOXIDANT THERAPY BEGUN AT THE TIME OF REPERFUSION - EVIDENCE THAT MYOCARDIAL STUNNING IS A MANIFESTATION OF REPERFUSION INJURY [J].
BOLLI, R ;
JEROUDI, MO ;
PATEL, BS ;
ARUOMA, OI ;
HALLIWELL, B ;
LAI, EK ;
MCCAY, PB .
CIRCULATION RESEARCH, 1989, 65 (03) :607-622
[10]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3