Degradation of chromosomal DNA during apoptosis

被引：343

作者：

Nagata, S

Nagase, H

Kawane, K

Mukae, N

Fukuyama, H

机构：

[1] Osaka Univ, Sch Med, Dept Genet, Japan Sci & Technol Corp, Osaka 5650871, Japan

[2] Japan Sci & Technol Corp, Grad Sch Frontier Sci, Integrated Biol Labs, Osaka 5650871, Japan

[3] Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Osaka 5650871, Japan

来源：

CELL DEATH AND DIFFERENTIATION | 2003年 / 10卷 / 01期

基金：

日本学术振兴会;

关键词：

apoptosis; DNase; DNA fragmentation; CAD; DNase II;

D O I：

10.1038/sj.cdd.4401161

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis is often accompanied by degradation of chromosomal DNA. CAD, caspase-activated DNase, was identified in 1998 as a DNase that is responsible for this process. In the last several years, mice deficient in the CAD system have been generated. Studies with these mice indicated that apoptotic DNA degradation occurs in two different systems. In one, the DNA fragmentation is carried out by CAD in the dying cells and in the other, by lysosomal DNase 11 after the dying cells are phagocytosed. Several other endonucleases have also been suggested as candidate effectors for the apoptotic degradation of chromosomal DNA. In this review, we will discuss the mechanism and role of DNA degradation during apoptosis.

引用

页码：108 / 116

页数：9

共 107 条

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