Autophagy: A New Mechanism of Prosurvival and Drug Resistance in Multiple Myeloma

被引：61

作者：

Desantis, V ^{[1
]}

Saltarella, I ^{[1
]}

Lamanuzzi, A. ^{[1
]}

Mariggio, M. A. ^{[2
]}

Racanelli, V ^{[1
]}

Vacca, Angelo ^{[1
]}

Frassanito, M. A. ^{[2
]}

机构：

[1] Univ Bari, Dept Biomed Sci & Human Oncol, Unit Internal Med & Clin Oncol, Aldo Moro Med Sch, Policlin Piazza Giulio Cesare 11, I-70124 Bari, Italy

[2] Univ Bari, Dept Biomed Sci & Human Oncol, Unit Gen Pathol, Aldo Moro Med Sch, Bari, Italy

来源：

TRANSLATIONAL ONCOLOGY | 2018年 / 11卷 / 06期

关键词：

CHAPERONE-MEDIATED AUTOPHAGY; REGULATES AUTOPHAGY; MOLECULAR MACHINERY; CANCER PROGRESSION; SIGNALING PATHWAY; CELL-DEATH; APOPTOSIS; MTOR; PROTEIN; GROWTH;

D O I：

10.1016/j.tranon.2018.08.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis. In physiological condition, autophagy funnels cytoplasmic constituents to autophagolysosomes for degradation and is an alternative way for cell-death behavior. Here, we inspected autophagy as a prosurvival mechanism essential for drug resistance in multiple myeloma (MM). Accordingly, autophagy inhibitors used in association to conventional anti-MM drugs might enforce the effect against resistant MM plasma cells and render autophagy a new therapeutic target.

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收藏

页码：1350 / 1357

页数：8

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