The Evolving Story in the Genetic Analysis for Heart Failure

被引：3

作者：

Miyazawa, Kazuo ^{[1
]}

Ito, Kaoru ^{[1
]}

机构：

[1] RIKEN Ctr Integrat Med Sci, Lab Cardiovasc Genom & Informat, Yokohama, Kanagawa, Japan

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2021年 / 8卷

关键词：

heart failure; cardiomyopathy; genetic architecture; genome-wide association study; big data;

D O I：

10.3389/fcvm.2021.646816

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genomic studies of cardiovascular diseases have achieved great success, not only in Mendelian genetic diseases such as hereditary arrhythmias and cardiomyopathies, but also in common diseases such as ischemic heart disease and atrial fibrillation. However, only limited success has been achieved in heart failure due to the complexity of its disease background. In this paper, we will review the genetic research for heart failure to date and discuss how we can discover new aspects of heart failure from the viewpoint of genomic perspective.

引用

页数：7

共 32 条

[1] Prevalence of Titin Truncating Variants in General Population
Akinrinade, Oyediran
Koskenvuo, Juha W.
Alastalo, Tero-Pekka
[J]. PLOS ONE, 2015, 10 (12):
[2] Phenotypic Refinement of Heart Failure in a National Biobank Facilitates Genetic Discovery
Aragam, Krishna G.
Chaffin, Mark
Levinson, Rebecca T.
McDermott, Gregory
Choi, Seung Hoan
Shoemaker, M. Benjamin
Haas, Mary E.
Weng, Lu-Chen
Lindsay, Mark E.
Smith, J. Gustav j
Newton-Cheh, Christopher
Roden, Dan M.
London, Barry
Wells, Quinn S.
Ellinor, Patrick T.
Kathiresan, Sekar
Lubitz, Steven A.
Bloom, Heather L.
Dudley, Samuel C.
Ellinor, Patrick T.
Shalaby, Alaa A.
Weiss, Raul
Gutmann, Rebecca
Saba, Samir
[J]. CIRCULATION, 2019, 139 (04) : 489 - 501
[3] Genome-Wide Analysis of Left Ventricular Image-Derived Phenotypes Identifies Fourteen Loci Associated With Cardiac Morphogenesis and Heart Failure Development
Aung, Nay
Vargas, Jose D.
Yang, Chaojie
Cabrera, Claudia P.
Warren, Helen R.
Fung, Kenneth
Tzanis, Evan
Barnes, Michael R.
Rotter, Jerome, I
Taylor, Kent D.
Manichaikul, Ani W.
Lima, Joao A. C.
Bluemke, David A.
Piechnik, Stefan K.
Neubauer, Stefan
Munroe, Patricia B.
Petersen, Steffen E.
[J]. CIRCULATION, 2019, 140 (16) : 1318 - 1330
[4] Dynamics of genome reorganization during human cardiogenesis reveal an RBM20-dependent splicing factory
Bertero, Alessandro
Fields, Paul A.
Ramani, Vijay
Bonora, Giancarlo
Yardimci, Galip G.
Reinecke, Hans
Pabon, Lil
Noble, William S.
Shendure, Jay
Murry, Charles E.
[J]. NATURE COMMUNICATIONS, 2019, 10 (1)
[5] Association of FADS1/2 Locus Variants and Polyunsaturated Fatty Acids With Aortic Stenosis
Chen, Hao Yu
Cairns, Benjamin J.
Small, Aeron M.
Burr, Hannah A.
Ambikkumar, Athithan
Martinsson, Andreas
Theriault, Sebastien
Munter, Hans Markus
Steffen, Brian
Zhang, Richard
Levinson, Rebecca T.
Shaffer, Christian M.
Rong, Jian
Sonestedt, Emily
Dufresne, Line
Ljungberg, Johan
Naslund, Ulf
Johansson, Bengt
Ranatunga, Dilrini K.
Whitmer, Rachel A.
Budoff, Matthew J.
Nguyen, Albert
Vasan, Ramachandran S.
Larson, Martin G.
Harris, William S.
Damrauer, Scott M.
Stark, Ken D.
Boekholdt, S. Matthijs
Wareham, Nicholas J.
Pibarot, Philippe
Arsenault, Benoit J.
Mathieu, Patrick
Gudnason, Vilmundur
O'Donnell, Christopher J.
Rotter, Jerome I.
Tsai, Michael Y.
Post, Wendy S.
Clarke, Robert
Soderberg, Stefan
Bosse, Yohan
Wells, Quinn S.
Smith, J. Gustav
Rader, Daniel J.
Lathrop, Mark
Engert, James C.
Thanassoulis, George
[J]. JAMA CARDIOLOGY, 2020, 5 (06) : 694 - 702
[6] Genetic association analyses highlight biological pathways underlying mitral valve prolapse
Dina, Christian
Bouatia-Naji, Nabila
Tucker, Nathan
Delling, Francesca N.
Toomer, Katelynn
Durst, Ronen
Perrocheau, Maelle
Fernandez-Friera, Leticia
Solis, Jorge
Le Tourneau, Thierry
Chen, Ming-Huei
Probst, Vincent
Bosse, Yohan
Pibarot, Philippe
Zelenika, Diana
Lathrop, Mark
Hercberg, Serge
Roussel, Ronan
Benjamin, Emelia J.
Bonnet, Fabrice
Lo, Su Hao
Dolmatova, Elena
Simonet, Floriane
Lecointe, Simon
Kyndt, Florence
Redon, Richard
Le Marec, Herve
Froguel, Philippe
Ellinor, Patrick T.
Vasan, Ramachandran S.
Bruneval, Patrick
Markwald, Roger R.
Norris, Russell A.
Milan, David J.
Slaugenhaupt, Susan A.
Levine, Robert A.
Schott, Jean-Jacques
Hagege, Albert A.
Jeunemaitre, Xavier
[J]. NATURE GENETICS, 2015, 47 (10) : 1206 - +
[7] Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation
Frey, Norbert
Frank, Derk
Lippl, Stefanie
Kuhn, Christian
Koegler, Harald
Barrientos, Tomasa
Rohr, Claudia
Will, Rainer
Mueller, Oliver J.
Weiler, Hartmut
Bassel-Duby, Rhonda
Katus, Hugo A.
Olson, Eric N.
[J]. JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (11) : 3598 - 3608
[8] Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy
Garcia-Pavia, Pablo
Kim, Yuri
Alejandra Restrepo-Cordoba, Maria
Lunde, Ida G.
Wakimoto, Hiroko
Smith, Amanda M.
Toepfer, Christopher N.
Getz, Kelly
Gorham, Joshua
Patel, Parth
Ito, Kaoru
Willcox, Jonathan A.
Arany, Zoltan
Li, Jian
Owens, Anjali T.
Govind, Risha
Nunez, Beatriz
Mazaika, Erica
Bayes-Genis, Antoni
Walsh, Roddy
Finkelman, Brian
Lupon, Josep
Whiffin, Nicola
Serrano, Isabel
Midwinter, William
Wilk, Alicja
Bardaji, Alfredo
Ingold, Nathan
Buchan, Rachel
Tayal, Upasana
Pascual-Figal, Domingo A.
de Marvao, Antonio
Ahmad, Mian
Manuel Garcia-Pinilla, Jose
Pantazis, Antonis
Dominguez, Fernando
Baksi, A. John
O'Regan, Declan P.
Rosen, Stuart D.
Prasad, Sanjay K.
Lara-Pezzi, Enrique
Provencio, Mariano
Lyon, Alexander R.
Alonso-Pulpon, Luis
Cook, Stuart A.
DePalma, Steven R.
Barton, Paul J. R.
Aplenc, Richard
Seidman, Jonathan G.
Ky, Bonnie
[J]. CIRCULATION, 2019, 140 (01) : 31 - 41
[9] Genetic Pathogenesis of Hypertrophic and Dilated Cardiomyopathy
Garfinkel, Amanda C.
Seidman, Jonathan G.
Seidman, Christine E.
[J]. HEART FAILURE CLINICS, 2018, 14 (02) : 139 - 146
[10] Identification and characterization of constrained non-exonic bases lacking predictive epigenomic and transcription factor binding annotations
Grujic, Olivera
Phung, Tanya N.
Kwon, Soo Bin
Arneson, Adriana
Lee, Yuju
Lohmueller, Kirk E.
Ernst, Jason
[J]. NATURE COMMUNICATIONS, 2020, 11 (01)

← 1 2 3 4 →