Hypoglycemic effect of Toumefortia hirsutissima L., on n-streptozotocin diabetic rats

被引：11

作者：

Andrade-Cetto, Adolfo ^{[1
]}

Revilla-Monsalve, Cristina

Wiedenfeld, Helmut

机构：

[1] Univ Nacl Autonoma Mexico, Fac Ciencias, Lab Etnofarmacol, Mexico City 04510, DF, Mexico

[2] Ctr Med Nacl SXXI, Unidad Invest Med & Enfermedades Metab, Mexico City 06725, DF, Mexico

[3] Univ Bonn, Inst Pharmaceut, D-53121 Bonn, Germany

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2007年 / 112卷 / 01期

关键词：

Tournefortia hirsutissima; hypoglycemic effect; n-Streptozotocin diabetic rats; type; 2; diabetes;

D O I：

10.1016/j.jep.2007.02.020

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The hypoglycemic effect of aqueous and butanolic extracts from Tournefortia hirsutissima (Boraginaceae) was determined on neonatal induced streptozotocin diabetic rats (n-STZ). Oral administration of water extracts at doses of 20 and 80 mg/kg, and butanolic extracts (8 and 80 mg/kg) significantly lowered the plasma glucose levels in diabetic rats within 3 It. Glibenclamide was used as reference and showed similar hypoglycemic effect. Our results support the traditional use of the plant as a hypoglycemic agent; we observe a dose-dependent action of the extracts. HPLC analysis confirmed that the aqueous and butanolic extracts had the same chemical composition. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：96 / 100

页数：5

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