Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research

被引：1
|
作者：
Timmermans, Steven [1 ,2 ]
Souffriau, Jolien [1 ,2 ]
Vandewalle, Jolien [1 ,2 ]
Van Wyngene, Lise [1 ,2 ]
Van Looveren, Kelly [1 ,2 ]
Vanderhaeghen, Tineke [1 ,2 ]
Libert, Claude [1 ,2 ]
机构：
[1] VIB Ctr Inflammat Res, Technol Pk 927, B-9052 Ghent, Belgium
[2] Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium
来源：
MAMMALIAN GENOME | 2018年 / 29卷 / 7-8期
关键词：
TUMOR-NECROSIS-FACTOR; LPS RESISTANCE; TNF; MICE; PROTECTS; SEPSIS; GENE; CYTOTOXICITY; LYMPHOCYTES; INHIBITION;
D O I：
10.1007/s00335-018-9751-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Inbred mouse strains derived from the species Mus spretus have been very informative in the study of certain gene polymorphisms in inflammation and infection. Based on our interest in sepsis, we used SPRET/EiJ mice and mapped several critical loci that are linked to sensitivity to cytokine-induced inflammation and endotoxemia. These studies were based on prominent phenotypes that have never been observed in strains derived from Mus musculus and we mapped them at a resolution that enables us to draw conclusions on the mechanisms. Now that the genome of SPRET/EiJ has been sequenced, and other tools have become available, it is time to revisit this strain and emphasize its advantages and disadvantages as a research tool and a discovery platform.
引用
收藏
页码：585 / 592
页数：8
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