Role of acetaldehyde in the induction of heart left ventricular atrial natriuretic peptide gene expression in rats

被引：11
作者：
Jänkälä, HP
Eriksson, CJP
Petersen, NE
Härkönen, M
Mäki, T
机构：
[1] Univ Helsinki, Cent Hosp, Dept Clin Chem, SF-00290 Helsinki, Finland
[2] Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, SF-00101 Helsinki, Finland
[3] Odense Univ Hosp, Dept Clin Chem, DK-5000 Odense, Denmark
来源：
ALCOHOL AND ALCOHOLISM | 2000年 / 35卷 / 04期
关键词：
D O I：
10.1093/alcalc/35.4.331
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
We studied the effects of ethanol and acetaldehyde on myocardial gene expression of atrial natriuretic peptide (ANP) and growth of rats. Combined ethanol and calcium carbimide treatment increased blood-acetaldehyde levels and ANP mRNA levels by 40-60% in 2-8 day experiments, compared to the controls. The results suggest a role for acetaldehyde in the development of alcoholic heart dysfunction.
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页码：331 / 335
页数：5
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