Cancer the'RBP'eutics-RNA-binding proteins as therapeutic targets for cancer

被引：135
作者：
Mohibi, Shakur
Chen, Xinbin
Zhang, Jin
机构：
[1] Univ Calif Davis, Sch Vet Med, Comparat Oncol Lab, Davis, CA 95616 USA
[2] Univ Calif Davis, Sch Med, Comparat Oncol Lab, Davis, CA 95616 USA
来源：
PHARMACOLOGY & THERAPEUTICS | 2019年 / 203卷
关键词：
RNA-binding proteins; RNA-binding domains; Cancer therapeutics; Small molecules; siRNA; Peptide; Aptamer; TRANSLATION INITIATION-FACTOR; CAP-DEPENDENT TRANSLATION; DEAD-BOX PROTEIN; AU-RICH ELEMENT; TUMOR-SUPPRESSOR GENE; NUCLEAR RIBONUCLEOPROTEIN K; SMALL-MOLECULE INHIBITION; P21; MESSENGER-RNA; EPITHELIAL-MESENCHYMAL TRANSITION; MYELOID CELL-PROLIFERATION;
D O I：
10.1016/j.pharmthera.2019.07.001
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes, including splicing, cleavage and polyadenylation, transport, translation and degradation of coding RNAs, non-coding RNAs and microRNAs. Recent studies indicate that RBPs not only play an instrumental role in normal cellular processes but have also emerged as major players in the development and spread of cancer. Herein, we review the current knowledge about RNA binding proteins and their role in tumorigenesis as well as the potential to target RBPs for cancer therapeutics. (C) 2019 Elsevier Inc. All rights reserved.
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页数：25
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