Coordinated Neutralization and Immune Activation by the Cytosolic Antibody Receptor TRIM21

被引：32

作者：

Fletcher, Adam J. ^{[1
]}

James, Leo C. ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Hills Rd, Cambridge CB2 2QH, England

来源：

JOURNAL OF VIROLOGY | 2016年 / 90卷 / 10期

基金：

欧洲研究理事会; 英国医学研究理事会;

关键词：

PROTEIN; VIRUS; FC;

D O I：

10.1128/JVI.00050-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

TRIM21 is a high-affinity antibody receptor uniquely expressed in the cytosol of mammalian cells. Here we summarize its role in extending antibody protection into the intracellular environment and allowing nonprofessional cells to benefit from adaptive immunity. We highlight recent work that has shed light on how TRIM21 acts as both an immune sensor and effector. We also review how TRIM21 synergizes with other innate immune receptors to promote an integrated antiviral response.

引用

页码：4856 / 4859

页数：4

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