Hippocampal FXR plays a role in the pathogenesis of depression: A preliminary study based on lentiviral gene modulation

被引：37

作者：

Chen, Wei-Guan ^{[1
]}

Zheng, Jia-Xuan ^{[1
]}

Xu, Xi ^{[1
]}

Hu, Yu-Ming ^{[1
]}

Ma, Yu-Min ^{[2
]}

机构：

[1] Nantong Univ, Affiliated Hosp, Dept Rehabil Med, Nantong 226001, Jiangsu, Peoples R China

[2] Second Peoples Hosp Nantong, Dept Internal Med, 43 XingRong St, Nantong 226002, Jiangsu, Peoples R China

来源：

PSYCHIATRY RESEARCH | 2018年 / 264卷

关键词：

Brain-derived neurotrophic factor; Depression; Farnesoid X receptor; Hippocampus; FARNESOID X RECEPTOR; FORCED SWIMMING TEST; TAIL SUSPENSION TEST; NEUROTROPHIC FACTORS; MOUSE MODEL; CREB; ANTIDEPRESSANTS; NEUROGENESIS; DISORDER; LIVER;

D O I：

10.1016/j.psychres.2018.04.025

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

As a well-known bile acid receptor, the role of Farnesoid X receptor (FXR) in the digestive system and cardiovascular system has been widely explored. However, there are very few studies involving FXR in the central nervous system. In this study, we explored the role of FXR in the pathogenesis of depression, a serious and worldwide neuropsychiatric disease. It was found that chronic unpredictable mild stress (CUMS) fully enhanced the protein and mRNA expressions of FXR in hippocampus, but not medial prefrontal cortex (mPFC). Overexpression of hippocampal FXR induced notable depressive-like behaviors and decreased expression of brain-derived neurotrophic factor (BDNF) in naive rats, while knockdown of hippocampal FXR fully prevented the effects of CUMS on rat behaviors and hippocampal BDNF expression. Taken together, our research extends the knowledge of FXR's role in the central nervous system, and may provide a potential and novel therapeutic target for treating depression.

引用

页码：374 / 379

页数：6

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