Prospective assessment of the natural history of positive D-dimer results in persons with acute venous thromboembolism (DVT or PE)

被引:28
作者
Kuruvilla, J
Wells, PS
Morrow, B
MacKinnon, K
Keeney, M
Kovacs, MJ
机构
[1] London Hlth Sci Ctr, Dept Hematol, London, ON N6A 4G5, Canada
[2] London Hlth Sci Ctr, Div Hematol, Dept Med, London, ON N6A 4G5, Canada
[3] Ottawa Civic Hosp, Dept Hematol, Ottawa, ON, Canada
[4] London Hlth Sci Ctr, Dept Hematol, London, ON, Canada
关键词
D-dimer; venous thromboembolism; recurrence; diagnosis; natural history;
D O I
10.1055/s-0037-1613444
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The natural history of initially positive D-dimers for venous thromboembolism is not known. If it returns to negative in the majority of patients, it would be potentially helpful to diagnose a recurrence. In this study, we prospectively measured D-dimer levels in outpatients with a diagnosis of venous thromboembolism. There were a total of 152 patients with an average age of 57. D-dimer results were performed at baseline and repeated at one week, one month and three months. At baseline 120 of 152 (79%) had a positive D-dimer result. Of those with an initially positive result, 80% were still positive at one week and 39% were still positive at one month. Finally at three months, 13% remained positive. Seven patients had recurrent events and all had persistently elevated D-climers at one month. This study suggests that a persistently positive D-dimer result after one month of treatment may indicate a higher risk of recurrent venous thromboembolism. D-dimer testing for the diagnosis of recurrence of venous thromboembolism deserves further study.
引用
收藏
页码:284 / 287
页数:4
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