Engineering AAV Vectors to Evade Innate Immune and Inflammatory Responses

被引:0
|
作者
Chan, Ying Kai [1 ,2 ]
Lim, Elaine [1 ,2 ]
Chan, Rigel [1 ,2 ]
Graveline, Amanda [1 ]
Letizia, Alexander [1 ,2 ]
Chiang, Jessica [1 ,2 ]
Vernet, Andyna [1 ]
Pezone, Matthew [1 ]
Church, George [1 ,2 ]
机构
[1] Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA
[2] Harvard Med Sch, Dept Genet, Boston, MA USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
1001
引用
收藏
页码:457 / 458
页数:2
相关论文
共 50 条
  • [1] Engineering AAV vectors to evade innate immune and inflammatory responses
    Chan, Y. K.
    HUMAN GENE THERAPY, 2018, 29 (12) : A19 - A19
  • [2] Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses
    Chan, Ying Kai
    Wang, Sean K.
    Chu, Colin J.
    Copland, David A.
    Letizia, Alexander J.
    Verdera, Helena Costa
    Chiang, Jessica J.
    Sethi, Meher
    Wang, May K.
    Neidermyer, William J., Jr.
    Chan, Yingleong
    Lim, Elaine T.
    Graveline, Amanda R.
    Sanchez, Melinda
    Boyd, Ryan F.
    Vihtelic, Thomas S.
    Inciong, Rolando Gian Carlo O.
    Slain, Jared M.
    Alphonse, Priscilla J.
    Xue, Yunlu
    Robinson-McCarthy, Lindsey R.
    Tam, Jenny M.
    Jabbar, Maha H.
    Sahu, Bhubanananda
    Adeniran, Janelle F.
    Muhuri, Manish
    Tai, Phillip W. L.
    Xie, Jun
    Krause, Tyler B.
    Vernet, Andyna
    Pezone, Matthew
    Xiao, Ru
    Liu, Tina
    Wang, Wei
    Kaplan, Henry J.
    Gao, Guangping
    Dick, Andrew D.
    Mingozzi, Federico
    McCall, Maureen A.
    Cepko, Constance L.
    Church, George M.
    SCIENCE TRANSLATIONAL MEDICINE, 2021, 13 (580)
  • [3] Innate immune responses to AAV vectors
    Rogers, Geoffrey L.
    Martino, Ashley T.
    Aslanidi, George V.
    Jayandharan, Giridhara R.
    Srivastava, Arun
    Herzog, Roland W.
    FRONTIERS IN MICROBIOLOGY, 2011, 2
  • [4] Engineering the AAV capsid to evade immune responses
    Barnes, Christopher
    Scheideler, Olivia
    Schaffer, David
    CURRENT OPINION IN BIOTECHNOLOGY, 2019, 60 : 99 - 103
  • [5] Novel Approaches in Engineering a Multipurpose AAV Vector Genome to Evade Both Innate and Adaptive Immune Responses
    Muhuri, Manish
    Xie, Jun
    Chan, Ying Kai
    Li, Jia
    Su, Qin
    Letizia, Alexander J.
    Church, George M.
    Tai, Phillip W. L.
    Gao, Guangping
    MOLECULAR THERAPY, 2020, 28 (04) : 181 - 181
  • [6] Developing an In Vitro Assay to Study Innate Immune Responses to AAV Vectors
    Baer, Alan
    Bhattarai, Nirjal
    MOLECULAR THERAPY, 2020, 28 (04) : 521 - 522
  • [7] Insulin as a Pharmaceutical Agent to Blunt Innate Immune Responses to AAV Vectors
    Martino, Ashley T.
    Qi, Tianxiang
    MOLECULAR THERAPY, 2018, 26 (05) : 107 - 108
  • [8] Ex Vivo and In Silico Modelling of Human Innate and Adaptive Immune Responses to AAV Vectors
    Benakanakere, Manju
    Jamwal, Deepa
    Kim, Kevin Yinho
    Ruiz, Maria
    Xicluna, Rebecca
    Haegel, Helene
    Wigbers, Manon
    Rose, Rachel
    Singh, Inderpal
    Mingozzi, Federico
    Kuranda, Klaudia
    MOLECULAR THERAPY, 2023, 31 (04) : 520 - 520
  • [9] A rational capsid-engineering strategy reduces innate and adaptive immune responses to Adeno-Associated Virus (AAV) Vectors
    Bentler, M.
    Hardet, R.
    Ertelt, M.
    Rudolf, D.
    Kaniowska, D.
    Schneider, A.
    Vondran, F. W. R.
    Schoeder, C. T.
    Delphin, M.
    Lucifora, J.
    Ott, M.
    Hacker, U. T.
    Adriouch, S.
    Buening, H.
    HUMAN GENE THERAPY, 2024, 35 (3-4) : A58 - A59
  • [10] Overcoming humoral immune responses to AAV vectors
    Mingozzi, Federico
    HUMAN GENE THERAPY, 2016, 27 (07) : A2 - A2