Topical acidic cream prevents the development of atopic dermatitis- and asthma-like lesions in murine model

被引:42
作者
Lee, Hae-Jin [1 ]
Yoon, Na Young [1 ]
Lee, Noo Ri [1 ]
Jung, Minyoung [1 ]
Kim, Dong Hye [1 ]
Choi, Eung Ho [1 ]
机构
[1] Yonsei Univ, Wonju Coll Med, Dept Dermatol, Wonju 220701, South Korea
基金
新加坡国家研究基金会;
关键词
acid; atopic dermatitis; atopic march; Dermatofagoides pteronyssinus; oxazolone; PROTEASE-ACTIVATED RECEPTOR-2; THYMIC STROMAL LYMPHOPOIETIN; STRATUM-CORNEUM INTEGRITY; AIRWAY INFLAMMATION; SKIN-BARRIER; EPICUTANEOUS SENSITIZATION; ALLERGIC INFLAMMATION; LANGERHANS CELLS; EPITHELIAL-CELLS; NC/NGA MICE;
D O I
10.1111/exd.12525
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Long-standing or repeated skin barrier damage followed by atopic dermatitis (AD) is the initial step of the atopic march that eventually progresses to respiratory allergies. Maintenance of an acidic pH in the stratum corneum (SC) is an important factor for normal skin barrier function. We performed this study to determine whether an oxazolone (Ox)-induced AD murine model can develop airway inflammation by topical application and nasal inhalation of a house dust mite, Dermatofagoides pteronyssinus (Dp), which is a novel atopic march animal model', and whether an acidic SC environment, made by repeated application of acidic cream, can interrupt this atopic march. During repeated treatment with Ox and Dp to make an atopic march murine model, acidic cream (pH 2.8) and neutral cream (pH 7.4) adjusted by citric acid and sodium hydroxide mixed with vehicle were applied twice daily. Repeated treatment with Ox and Dp to hairless mice induced AD-like skin lesions followed by respiratory allergy, defining it as an atopic march model. Acidic cream inhibited the occurrence of respiratory allergic inflammation as well as AD-like skin lesions. These results indicate that a novel atopic march animal model can be developed by repeated topical and nasal treatments with house dust mite on Ox-induced AD mice and that the acidification of SC could be a novel intervention method to block the atopic march.
引用
收藏
页码:736 / 741
页数:6
相关论文
共 45 条
[21]   Murine atopic dermatitis responds to peroxisome proliferator-activated receptors α and β/δ (but not γ) and liver X receptor activators [J].
Hatano, Yutaka ;
Man, Mao-Qiang ;
Uchida, Yoshikazu ;
Crumrine, Debra ;
Mauro, Theodora M. ;
Feingold, Kenneth R. ;
Elias, Peter M. ;
Holleran, Walter M. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2010, 125 (01) :160-169
[22]   Maintenance of an Acidic Stratum Corneum Prevents Emergence of Murine Atopic Dermatitis [J].
Hatano, Yutaka ;
Man, Mao-Qiang ;
Uchida, Yoshikazu ;
Crumrine, Debra ;
Scharschmidt, Tiffany C. ;
Kim, Esther G. ;
Mauro, Theodora M. ;
Feingold, Kenneth R. ;
Elias, Peter M. ;
Holleran, Walter M. .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (07) :1824-1835
[23]   Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13 [J].
He, Rui ;
Kim, Hye Young ;
Yoon, Juhan ;
Oyoshi, Michiko K. ;
MacGinnitie, Andrew ;
Goya, Sho ;
Freyschmidt, Eva-Jasmin ;
Bryce, Paul ;
McKenzie, Andrew N. J. ;
Umetsu, Dale T. ;
Oettgen, Hans C. ;
Geha, Raif S. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (04) :761-770
[24]   Cutting Edge: Persistence of Increased Mast Cell Numbers in Tissues Links Dermatitis to Enhanced Airway Disease in a Mouse Model of Atopy [J].
Hershko, Alon Y. ;
Charles, Nicolas ;
Olivera, Ana ;
Alvarez-Errico, Damiana ;
Rivera, Juan .
JOURNAL OF IMMUNOLOGY, 2012, 188 (02) :531-535
[25]   Topical calcitriol restores the impairment of epidermal permeability and antimicrobial barriers induced by corticosteroids [J].
Hong, S. P. ;
Oh, Y. ;
Jung, M. ;
Lee, S. ;
Jeon, H. ;
Cho, M-Y. ;
Lee, S. H. ;
Choi, E. H. .
BRITISH JOURNAL OF DERMATOLOGY, 2010, 162 (06) :1251-1260
[26]   Cytokine modulation of atopic dermatitis filaggrin skin expression (Reprinted from J Allergy Clin Immunol vol 120, pg 150-5, 2007) [J].
Howell, Michael D. ;
Kim, Byung Eui ;
Gao, Peisong ;
Grant, Audrey V. ;
Boguniewicz, Mark ;
DeBenedetto, Anna ;
Schneider, Lynda ;
Beck, Lisa A. ;
Barnes, Kathleen C. ;
Leung, Donald Y. M. .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2009, 124 (03) :R7-R12
[27]   IL-1α Stimulation Restores Epidermal Permeability and Antimicrobial Barriers Compromised by Topical Tacrolimus [J].
Jung, Ye-Jin ;
Jung, Minyoung ;
Kim, Minjeong ;
Hong, Seung-Phil ;
Choi, Eung Ho .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (03) :698-705
[28]   Aggravation of atopic dermatitis-like symptoms by consecutive low concentration of formaldehyde exposure in NC/Nga mice [J].
Kim, Ji-Yun ;
Jeong, Mi Sook ;
Park, Kui Young ;
Seo, Seong Jun .
EXPERIMENTAL DERMATOLOGY, 2013, 22 (03) :219-221
[29]   Proteases Induce Production of Thymic Stromal Lymphopoietin by Airway Epithelial Cells through Protease-Activated Receptor-2 [J].
Kouzaki, Hideaki ;
O'Grady, Scott M. ;
Lawrence, Christopher B. ;
Kita, Hirohito .
JOURNAL OF IMMUNOLOGY, 2009, 183 (02) :1427-1434
[30]   Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases [J].
Kubo, Akiharu ;
Nagao, Keisuke ;
Amagai, Masayuki .
JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (02) :440-447