The association of renal cell carcinoma with gastrointestinal stromal tumors

被引:7
作者
Mendonca, Shawn J. [1 ,2 ,3 ]
Sanchez, Alejandro [1 ,2 ]
Blum, Kyle A. [1 ,2 ]
Ghanaat, Mazyar [1 ,2 ]
Kashan, Mahyar Y. [1 ,2 ]
Benfante, Nicole [1 ,2 ]
Russo, Paul [1 ,2 ]
Coleman, Jonathan A. [1 ,2 ]
Crago, Aimee M. [4 ]
Hakimi, A. Ari [1 ,2 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Dept Surg, Div Urol, Sidney Kimmel Ctr Prostate, 1275 York Ave, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Urol Canc, 1275 York Ave, New York, NY 10021 USA
[3] Northwell Hlth, Lenox Hill Hosp, Dept Urol, 170 E 77th St,Suite B, New York, NY 10075 USA
[4] Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA
关键词
clinical association; gastrointestinal stromal tumors; renal cell carcinoma; INTERFERON-ALPHA; SUNITINIB; GERMLINE; GIST; EPIDEMIOLOGY; COEXISTENCE; MUTATIONS; NEOPLASMS; SURVIVAL; BIOLOGY;
D O I
10.1002/jso.25080
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background and ObjectivesPrior small studies have reported a possible association between renal cell carcinoma (RCC) and gastrointestinal stromal tumors (GISTs). In the largest known series, our objective was to describe the prevalence of RCC among patients with GISTs over 26 years at Memorial Sloan Kettering Cancer Center (MSKCC). MethodsWe retrospectively reviewed MSKCC's prospectively maintained sarcoma and RCC databases and identified all patients with both RCC and GIST between 1980 and 2016. Demographic and clinicopathological characteristics were obtained. ResultsA total of 9/405 (2.2%) GIST patients were identified with RCC, with a mean follow-up of 9.2 (range 3.8-28.4) years. Five out of nine (55.6%) patients had RCC and GIST diagnosis within 6 months of each other. Mean RCC tumor size was 3.0 (range 1.8-8) cm and 8/9 (88.9%) patients were RCC stage 1. A total of 4/9 (44.4%) patients had papillary RCC (pRCC) histology, 5/9 (55.6%) had additional alternative malignancies, and 4/9 (44.4%) had primary small bowel GIST. ConclusionsOur series suggests a possible association of RCC with GISTs. In addition, we found a high frequency of pRCC histology, alternative malignancies, and small bowel GISTs in co-occurring RCC-GIST patients. Further investigation to identify genetic mutations, in this population, would assist in surveillance and treatment.
引用
收藏
页码:1716 / 1720
页数:5
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