Neuregulin-1 is a Chemoattractant and Chemokinetic Molecule for Trunk Neural Crest Cells

被引：12
作者：
De Bellard, Maria Elena [1 ]
Ortega, Blanca [1 ]
Sao, Sothy [1 ]
Kim, Lino [1 ]
Herman, Joshua [1 ]
Zuhdi, Nora [1 ]
机构：
[1] Calif State Univ Northridge, Biol Dept, MC 8303,18111 Nordhoff St, Northridge, CA 91330 USA
来源：
DEVELOPMENTAL DYNAMICS | 2018年 / 247卷 / 07期
基金：
美国国家卫生研究院;
关键词：
Neuregulin; chick; trunk neural crest; NRG1; cell migration; chemotaxis; chemokinesis; positive guidance; sympathetic ganglion; chemoattraction; MIGRATION; GUIDANCE; ERBB2; EXPRESSION; RECEPTORS; PATTERN; MYELINATION; INHIBITION; GRADIENTS; DYNAMICS;
D O I：
10.1002/dvdy.24625
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Background: Trunk neural crest cells migrate rapidly along characteristic pathways within the developing vertebrate embryo. Proper trunk neural crest cell migration is necessary for the morphogenesis of much of the peripheral nervous system, melanocytes, and the adrenal medulla. Numerous molecules help guide trunk neural crest cell migration throughout the early embryo. Results: The trophic factor NRG1 is a chemoattractant through in vitro chemotaxis assays and in vivo silencing via a DN-erbB receptor. Interestingly, we also observed changes in migratory responses consistent with a chemokinetic effect of NRG1 in trunk neural crest velocity. Conclusions: NRG1 is a trunk neural crest cell chemoattractant and chemokinetic molecule. (C) 2018 Wiley Periodicals, Inc.
引用
收藏
页码：888 / 902
页数：15
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