Neuregulin-1 is a Chemoattractant and Chemokinetic Molecule for Trunk Neural Crest Cells

被引：12

作者：

De Bellard, Maria Elena ^{[1
]}

Ortega, Blanca ^{[1
]}

Sao, Sothy ^{[1
]}

Kim, Lino ^{[1
]}

Herman, Joshua ^{[1
]}

Zuhdi, Nora ^{[1
]}

机构：

[1] Calif State Univ Northridge, Biol Dept, MC 8303,18111 Nordhoff St, Northridge, CA 91330 USA

来源：

DEVELOPMENTAL DYNAMICS | 2018年 / 247卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Neuregulin; chick; trunk neural crest; NRG1; cell migration; chemotaxis; chemokinesis; positive guidance; sympathetic ganglion; chemoattraction; MIGRATION; GUIDANCE; ERBB2; EXPRESSION; RECEPTORS; PATTERN; MYELINATION; INHIBITION; GRADIENTS; DYNAMICS;

D O I：

10.1002/dvdy.24625

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Background: Trunk neural crest cells migrate rapidly along characteristic pathways within the developing vertebrate embryo. Proper trunk neural crest cell migration is necessary for the morphogenesis of much of the peripheral nervous system, melanocytes, and the adrenal medulla. Numerous molecules help guide trunk neural crest cell migration throughout the early embryo. Results: The trophic factor NRG1 is a chemoattractant through in vitro chemotaxis assays and in vivo silencing via a DN-erbB receptor. Interestingly, we also observed changes in migratory responses consistent with a chemokinetic effect of NRG1 in trunk neural crest velocity. Conclusions: NRG1 is a trunk neural crest cell chemoattractant and chemokinetic molecule. (C) 2018 Wiley Periodicals, Inc.

引用

页码：888 / 902

页数：15

共 70 条

[1]

Armisén R, 2002, J NEUROSCI, V22, P8347

[2] Premigratory and Migratory Neural Crest Cells Are Multipotent In Vivo [J].

Baggiolini, Arianna ;

Varum, Sandra ;

Mateos, Jose Maria ;

Bettosini, Damiano ;

John, Nessy ;

Bonalli, Mario ;

Ziegler, Urs ;

Dimou, Leda ;

Clevers, Hans ;

Furrer, Reinhard ;

Sommer, Lukas .

CELL STEM CELL, 2015, 16 (03) :314-322

[3]

BAKER CV, 2005, DEV NEUROBIOL, P67

[4] CHEMOTACTIC EFFECT OF MIXTURES OF ANTIBODY AND ANTIGEN ON POLYMORPHONUCLEAR LEUCOCYTES [J].

BOYDEN, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1962, 115 (03) :453-&

[5] A microfluidic imaging chamber for the direct observation of chemotactic transmigration [J].

Breckenridge, Mark T. ;

Egelhoff, Thomas T. ;

Baskaran, Harihara .

BIOMEDICAL MICRODEVICES, 2010, 12 (03) :543-553

[6] The ErbB2 and ErbB3 receptors and their ligand, neuregulin-1, are essential for development of the sympathetic nervous system [J].

Britsch, S ;

Li, L ;

Kirchhoff, S ;

Theuring, F ;

Brinkmann, V ;

Birchmeier, C ;

Riethmacher, D .

GENES & DEVELOPMENT, 1998, 12 (12) :1825-1836

[7] Manipulations of neural crest cells or their migratory pathways [J].

Bronner-Fraser, Marianne ;

Garcia-Castrot, Martin .

AVIAN EMBRYOLOGY, 2ND EDITION, 2008, 87 :75-96

[8]

BRONNERFRASER M, 1991, DEVELOPMENT, P17

[9] Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation [J].

Budi, Erine H. ;

Patterson, Larissa B. ;

Parichy, David M. .

DEVELOPMENT, 2008, 135 (15) :2603-2614

[10] Contact inhibition of locomotion in vivo controls neural crest directional migration [J].

Carmona-Fontaine, Carlos ;

Matthews, Helen K. ;

Kuriyama, Sei ;

Moreno, Mauricio ;

Dunn, Graham A. ;

Parsons, Maddy ;

Stern, Claudio D. ;

Mayor, Roberto .

NATURE, 2008, 456 (7224) :957-961

← 1 2 3 4 5 6 7 →