DNA Copy Number Variations as Markers of Mutagenic Impact

被引：25
作者：
Hovhannisyan, Galina [1 ]
Harutyunyan, Tigran [1 ]
Aroutiounian, Rouben [1 ]
Liehr, Thomas [2 ]
机构：
[1] Yerevan State Univ, Dept Genet & Cytol, Alex Manoogian 1, Yerevan 0025, Armenia
[2] Friedrich Schiller Univ, Jena Univ Hosp, Inst Human Genet, Klinikum 1, D-07747 Jena, Germany
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 19期
基金：
俄罗斯科学基金会;
关键词：
copy number variation; human; animal and plant cells; chemical mutagens; radiation; IONIZING-RADIATION; ALLELIC IMBALANCE; VARIANTS; GENOME; MECHANISMS; MUTATIONS; INSTABILITY; IRRADIATION; DISRUPTION; EXPRESSION;
D O I：
10.3390/ijms20194723
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DNA copy number variation (CNV) occurs due to deletion or duplication of DNA segments resulting in a different number of copies of a specific DNA-stretch on homologous chromosomes. Implications of CNVs in evolution and development of different diseases have been demonstrated although contribution of environmental factors, such as mutagens, in the origin of CNVs, is poorly understood. In this review, we summarize current knowledge about mutagen-induced CNVs in human, animal and plant cells. Differences in CNV frequencies induced by radiation and chemical mutagens, distribution of CNVs in the genome, as well as adaptive effects in plants, are discussed. Currently available information concerning impact of mutagens in induction of CNVs in germ cells is presented. Moreover, the potential of CNVs as a new endpoint in mutagenicity test-systems is discussed.
引用
收藏
页数：19
相关论文
共 85 条
  • [1] The genome-wide effects of ionizing radiation on mutation induction in the mammalian germline
    Adewoye, Adeolu B.
    Lindsay, Sarah J.
    Dubrova, Yuri E.
    Hurles, Matthew E.
    [J]. NATURE COMMUNICATIONS, 2015, 6
  • [2] Effects of hydroxyurea on CNV induction in the mouse germline
    Arlt, Martin F.
    Rajendran, Sountharia
    Holmes, Sandra N.
    Wang, Kathleen
    Bergin, Ingrid L.
    Ahmed, Samreen
    Wilson, Thomas E.
    Glover, Thomas W.
    [J]. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2018, 59 (08) : 698 - 714
  • [3] Copy Number Variants Are Produced in Response to Low-Dose Ionizing Radiation in Cultured Cells
    Arlt, Martin F.
    Rajendran, Sountharia
    Birkeland, Shanda R.
    Wilson, Thomas E.
    Glover, Thomas W.
    [J]. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2014, 55 (02) : 103 - 113
  • [4] De Novo CNV Formation in Mouse Embryonic Stem Cells Occurs in the Absence of Xrcc4-Dependent Nonhomologous End Joining
    Arlt, Martin F.
    Rajendran, Sountharia
    Birkeland, Shanda R.
    Wilson, Thomas E.
    Glover, Thomas W.
    [J]. PLOS GENETICS, 2012, 8 (09):
  • [5] Replication stress and mechanisms of CNV formation
    Arlt, Martin F.
    Wilson, Thomas E.
    Glover, Thomas W.
    [J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2012, 22 (03) : 204 - 210
  • [6] Hydroxyurea induces de novo copy number variants in human cells
    Arlt, Martin F.
    Ozdemir, Alev Cagla
    Birkeland, Shanda R.
    Wilson, Thomas E.
    Glover, Thomas W.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (42) : 17360 - 17365
  • [7] Comparison of Constitutional and Replication Stress-Induced Genome Structural Variation by SNP Array and Mate-Pair Sequencing
    Arlt, Martin F.
    Ozdemir, Alev Cagla
    Birkeland, Shanda R.
    Lyons, Robert H., Jr.
    Glover, Thomas W.
    Wilson, Thomas E.
    [J]. GENETICS, 2011, 187 (03) : 675 - 683
  • [8] Replication Stress Induces Genome-wide Copy Number Changes in Human Cells that Resemble Polymorphic and Pathogenic Variants
    Arlt, Martin F.
    Mulle, Jennifer G.
    Schaibley, Valerie M.
    Ragland, Ryan L.
    Durkin, Sandra G.
    Warren, Stephen T.
    Glover, Thomas W.
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2009, 84 (03) : 339 - 350
  • [9] Paternal exposure to benzo(a)pyrene induces genome-wide mutations in mouse offspring
    Beal, Marc A.
    Meier, Matthew J.
    Williams, Andrew
    Rowan-Carroll, Andrea
    Gagne, Remi
    Lindsay, Sarah J.
    Fitzgerald, Tomas
    Hurles, Matthew E.
    Marchetti, Francesco
    Yauk, Carole L.
    [J]. COMMUNICATIONS BIOLOGY, 2019, 2 (1)
  • [10] The challenges and importance of structural variation detection in livestock
    Bickhart, Derek M.
    Liu, George E.
    [J]. FRONTIERS IN GENETICS, 2014, 5
123456789