DNA and RNA oligonucleotides as a new class of drugs

被引：0

作者：

Radomska-Lesniewska, Dorota ^{[1
]}

Hevelke, Agata ^{[1
]}

Jankowska-Steifer, Ewa ^{[1
]}

Malejczyk, Jacek ^{[1
]}

机构：

[1] Warsaw Med Univ, Dept Histol & Embryol, Ctr Biostruct Res, PL-02004 Warsaw, Poland

来源：

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY | 2009年 / 34卷 / 04期

关键词：

aptamer; DNA; RNA; cancer therapy; ocular diseases; viral diseases; circulations disorders; APTAMERS; GROWTH; DISCOVERY; PROTEIN; VEGF;

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Aptamers are short synthetic single-stranded DNA or RNA oligonucleotides forming unique 3-D conformation. They are able to bind and neutralize their tat-get molecules with high specificity and affinity. Therefore, they may specifically interfere in vivo with some protein function and thus display drug-like properties. This paper provides a brief description of possible clinical application of aptamers arguing for their tremendous therapeutic possibilities.

引用

页码：280 / 283

页数：4

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