Label-free electrochemical microfluidic biosensors: futuristic point-of-care analytical devices for monitoring diseases

被引：44

作者：

Ebrahimi, Ghasem ^{[1
,2
]}

Pakchin, Parvin Samadi ^{[1
]}

Shamloo, Amir ^{[3
]}

Mota, Ali ^{[2
]}

de la Guardia, Miguel ^{[4
]}

Omidian, Hossein ^{[5
]}

Omidi, Yadollah ^{[5
]}

机构：

[1] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Biomed Inst, Tabriz, Iran

[2] Tabriz Univ Med Sci, Fac Med Sci, Dept Biochem & Clin Labs, Tabriz, Iran

[3] Sharif Univ Technol, Sch Mech Engn, Tehran, Iran

[4] Univ Valencia, Dept Analyt Chem, Valencia, Spain

[5] Nova Southeastern Univ, Coll Pharm, Dept Pharmaceut Sci, Ft Lauderdale, FL 33328 USA

来源：

MICROCHIMICA ACTA | 2022年 / 189卷 / 07期

关键词：

Biosensor; Electrochemical detection; Label-free sensing; Microfluidics; Point-of-care; HIGHLY SENSITIVE DETECTION; CANCER-CELLS; PAPER; SENSOR; CHIP; APTASENSOR; DNA; IMMUNOSENSOR; PLATFORM; SYSTEM;

D O I：

10.1007/s00604-022-05316-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The integration of microfluidics with electrochemical analysis has resulted in the development of single miniaturized detection systems, which allows the precise control of sample volume with multi-analyte detection capability in a cost- and time-effective manner. Microfluidic electrochemical sensing devices (MESDs) can potentially serve as precise sensing and monitoring systems for the detection of molecular markers in various detrimental diseases. MESDs offer several advantages, including (i) automated sample preparation and detection, (ii) low sample and reagent requirement, (iii) detection of multianalyte in a single run, (iv) multiplex analysis in a single integrated device, and (v) portability with simplicity in application and disposability. Label-free MESDs can serve an affordable real-time detection with a simple analysis in a short processing time, providing point-of-care diagnosis/detection possibilities in precision medicine, and environmental analysis. In the current review, we elaborate on label-free microfluidic biosensors, provide comprehensive insights into electrochemical detection techniques, and discuss the principles of label-free microfluidic-based sensing approaches.

引用

页数：18

共 101 条

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