Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis

被引：34

作者：

Heinzelmann, Katharina ^{[1
,2
,3
]}

Hu, Qianjiang ^{[1
,2
,4
]}

Hu, Yan ^{[3
]}

Dobrinskikh, Evgenia ^{[3
]}

Ansari, Meshal ^{[1
,2
]}

Melo-Narvaez, M. Camila ^{[1
,2
]}

Ulke, Henrik M. ^{[1
,2
]}

Leavitt, Colton ^{[3
]}

Mirita, Carol ^{[5
]}

Trudeau, Tammy ^{[3
]}

Saal, Maxwell L. ^{[3
]}

Rice, Pamela ^{[5
]}

Gao, Bifeng ^{[3
]}

Janssen, William J. ^{[3
,6
]}

Yang, Ivana V. ^{[3
]}

Schiller, Herbert B. ^{[1
,2
]}

Vladar, Eszter K. ^{[3
,7
]}

Lehmann, Mareike ^{[1
,2
]}

Koeigshoff, Melanie ^{[4
]}

机构：

[1] Helmholtz Zentrum Munchen, Inst Lung Hlth & Immun, Comprehens Pneumol Ctr Munich, Munich, Germany

[2] German Ctr Lung Res DZL, Munich, Germany

[3] Univ Colorado, Div Pulm Sci & Crit Care Med, Dept Med, Sch Med, Aurora, CO 80045 USA

[4] Univ Pittsburgh, Sch Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA USA

[5] Eastern Colorado VA Healthcare Syst, Rocky Mt Reg VA Med Ctr, Aurora, CO USA

[6] Natl Jewish Hlth, Div Pulm Crit Care & Sleep Med, Dept Med, Denver, CO USA

[7] Univ Colorado, Dept Cell & Dev Biol, Sch Med, Aurora, CO USA

来源：

EUROPEAN RESPIRATORY JOURNAL | 2022年 / 59卷 / 06期

关键词：

GPR87;

D O I：

10.1183/13993003.02373-2021

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

引用

页数：5

共 17 条

[1] Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis [J].

Adams, Taylor S. ;

Schupp, Jonas C. ;

Poli, Sergio ;

Ayaub, Ehab A. ;

Neumark, Nir ;

Ahangari, Farida ;

Chu, Sarah G. ;

Raby, Benjamin A. ;

DeTullis, Giuseppe ;

Januszyk, Michael ;

Duan, Qiaonan ;

Arnett, Heather A. ;

Siddiqui, Asim ;

Washko, George R. ;

Homer, Robert ;

Yan, Xiting ;

Rosas, Ivan O. ;

Kaminski, Naftali .

SCIENCE ADVANCES, 2020, 6 (28)

[2] Single-Cell Reconstruction of Human Basal Cell Diversity in Normal and Idiopathic Pulmonary Fibrosis Lungs [J].

Carraro, Gianni ;

Mulay, Apoorva ;

Yao, Changfu ;

Mizuno, Takako ;

Konda, Bindu ;

Petrov, Martin ;

Lafkas, Daniel ;

Arron, Joe R. ;

Hogaboam, Cory M. ;

Chen, Peter ;

Jiang, Dianhua ;

Noble, Paul W. ;

Randell, Scott H. ;

McQualter, Jonathan L. ;

Stripp, Barry R. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 202 (11) :1540-1550

[3] Abnormal re-epithelialization and lung remodeling in idiopathic pulmonary fibrosis:: The role of ΔN-p63 [J].

Chilosi, M ;

Poletti, V ;

Murer, B ;

Lestani, M ;

Cancellieri, A ;

Montagna, L ;

Piccoli, P ;

Cangi, G ;

Semenzato, G ;

Doglioni, C .

LABORATORY INVESTIGATION, 2002, 82 (10) :1335-1345

[4] A Single-Cell Atlas of the Human Healthy Airways [J].

Deprez, Marie ;

Zaragosi, Laure-Emmanuelle ;

Truchi, Marin ;

Becavin, Christophe ;

Garcia, Sandra Ruiz ;

Arguel, Marie-Jeanne ;

Plaisant, Magali ;

Magnone, Virginie ;

Lebrigand, Kevin ;

Abelanet, Sophie ;

Brau, Frederic ;

Paquet, Agnes ;

Pe'er, Dana ;

Marquette, Charles-Hugo ;

Leroy, Sylvie ;

Barbry, Pascal .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 202 (12) :1636-1645

[5] Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis [J].

Habermann, Arun C. ;

Gutierrez, Austin J. ;

Bui, Linh T. ;

Yahn, Stephanie L. ;

Winters, Nichelle, I ;

Calvi, Carla L. ;

Peter, Lance ;

Chung, Mei-, I ;

Taylor, Chase J. ;

Jetter, Christopher ;

Raju, Latha ;

Roberson, Jamie ;

Ding, Guixiao ;

Wood, Lori ;

Sucre, Jennifer M. S. ;

Richmond, Bradley W. ;

Serezani, Ana P. ;

McDonnell, Wyatt J. ;

Mallal, Simon B. ;

Bacchetta, Matthew J. ;

Loyd, James E. ;

Shaver, Ciara M. ;

Ware, Lorraine B. ;

Bremner, Ross ;

at Walia, Raj ;

Blackwell, Timothy S. ;

Banovich, Nicholas E. ;

Kropski, Jonathan A. .

SCIENCE ADVANCES, 2020, 6 (28)

[6] Muc5b overexpression causes mucociliary dysfunction and enhances lung fibrosis in mice [J].

Hancock, Laura A. ;

Hennessy, Corinne E. ;

Solomon, George M. ;

Dobrinskikh, Evgenia ;

Estrella, Alani ;

Hara, Naoko ;

Hill, David B. ;

Kissner, William J. ;

Markovetz, Matthew R. ;

Villalon, Diane E. Grove ;

Voss, Matthew E. ;

Tearney, Guillermo J. ;

Carroll, Kate S. ;

Shi, Yunlong ;

Schwarz, Marvin I. ;

Thelin, William R. ;

Rowe, Steven M. ;

Yang, Ivana V. ;

Evans, Christopher M. ;

Schwartz, David A. .

NATURE COMMUNICATIONS, 2018, 9

[7] Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis [J].

Reyfman, Paul A. ;

Walter, James M. ;

Joshi, Nikita ;

Anekalla, Kishore R. ;

McQuattie-Pimentel, Alexandra C. ;

Chiu, Stephen ;

Fernandez, Ramiro ;

Akbarpour, Mahzad ;

Chen, Ching-, I ;

Ren, Ziyou ;

Verma, Rohan ;

Abdala-Valencia, Hiam ;

Nam, Kiwon ;

Chi, Monica ;

Han, SeungHye ;

Gonzalez-Gonzalez, Francisco J. ;

Soberanes, Saul ;

Watanabe, Satoshi ;

Williams, Kinola J. N. ;

Flozak, Annette S. ;

Nicholson, Trevor T. ;

Morgan, Vince K. ;

Winter, Deborah R. ;

Hinchcliff, Monique ;

Hrusch, Cara L. ;

Guzy, Robert D. ;

Bonham, Catherine A. ;

Sperling, Anne, I ;

Bag, Remzi ;

Hamanaka, Robert B. ;

Mutlu, Gokhan M. ;

Yeldandi, Anjana, V ;

Marshall, Stacy A. ;

Shilatifard, Ali ;

Amaral, Luis A. N. ;

Perlman, Harris ;

Sznajder, Jacob, I ;

Argento, A. Christine ;

Gillespie, Colin T. ;

Dematte, Jane ;

Jain, Manu ;

Singer, Benjamin D. ;

Ridge, Karen M. ;

Lam, Anna P. ;

Bharat, Ankit ;

Bhorade, Sangeeta M. ;

Gottardi, Cara J. ;

Budinger, G. R. Scott ;

Misharin, Alexander, V .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2019, 199 (12) :1517-1536

[8] Basal cells as stem cells of the mouse trachea and human airway epithelium [J].

Rock, Jason R. ;

Onaitis, Mark W. ;

Rawlins, Emma L. ;

Lu, Yun ;

Clark, Cheryl P. ;

Xue, Yan ;

Randell, Scott H. ;

Hogan, Brigid L. M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (31) :12771-12775

[9] NIH Image to ImageJ: 25 years of image analysis [J].

Schneider, Caroline A. ;

Rasband, Wayne S. ;

Eliceiri, Kevin W. .

NATURE METHODS, 2012, 9 (07) :671-675

[10] The Idiopathic Pulmonary Fibrosis Honeycomb Cyst Contains A Mucocilary Pseudostratified Epithelium [J].

Seibold, Max A. ;

Smith, Russell W. ;

Urbanek, Cydney ;

Groshong, Steve D. ;

Cosgrove, Gregory P. ;

Brown, Kevin K. ;

Schwarz, Marvin I. ;

Schwartz, David A. ;

Reynolds, Susan D. .

PLOS ONE, 2013, 8 (03)

← 1 2 →