Reactive Oxygen Species Responsive Cleavable Hierarchical Metallic Supra-Nanostructure

被引：18
作者：
Choi, Hyunjun [1 ,2 ]
Choi, Bongseo [1 ]
Han, Jun-Hyeok [3 ]
Shin, Ha Eun [3 ]
Park, Wooram [3 ,4 ]
Kim, Dong-Hyun [1 ,2 ,5 ]
机构：
[1] Northwestern Univ, Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USA
[2] Univ Illinois, Dept Biomed Engn, Chicago, IL 60607 USA
[3] Sungkyunkwan Univ, Dept Integrat Biotechnol, Coll Biotechnol & Bioengn, Seobur 2066, Suwon 16419, Gyeonggi, South Korea
[4] McCormick Sch Engn, Dept Biomed Engn, Evanston, IL 60208 USA
[5] Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA
来源：
SMALL | 2022年 / 18卷 / 38期
关键词：
cancer therapy; degradable metal nanoparticles; degradable nanostructures; gold nanoparticles; reactive oxygen species; GOLD NANOPARTICLES; OXIDATION; THERAPY;
D O I：
10.1002/smll.202202694
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A reactive oxygen species (ROS) responsive cleavable hierarchical metallic supra-nanostructure (HMSN) is reported. HMSN structured with thin branches composed of primary gold (Au) nanocrystals and silver (Ag) nano-linkers is synthesized by a one-pot aqueous synthesis with a selected ratio of Au/Ag/cholate. ROS responsive degradability of HMSN is tested in the presence of endogenous and exogeneous ROS. Significant ROS-responsive structural deformation of HMSN is observed in the ROS exposure with hydrogen peroxide (H2O2) solution. The ROS responsiveness of HMSN is significantly comparable with negligible structural changes of conventional spherical gold nanoparticles. The demonstrated ROS responsive degradation of HMSN is further confirmed in various in vitro ROS conditions of each cellular endogenous ROS and exogeneous ROS generated by photodynamic therapy (PDT) or X-ray radiation. Then, in vivo ROS responsive degradability of HMSN is further evaluated with intratumoral injection of HMSN and exogeneous ROS generation via PDT in a mouse tumor model. Additional in vivo biodistribution and toxicity of intravenously administrated HMSN at 30-day post-injection are investigated for potential in vivo applications. The observed ROS responsive degradability of HMSN will provide a promising option for a type of ROS responsive-multifunctional nanocarriers in cancer treatment and various biomedical applications.
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页数：10
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