Organoid Models for Infectious Disease

被引：29
作者：
Blutt, Sarah E. [1 ,2 ]
Estes, Mary K. [1 ,3 ]
机构：
[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
来源：
ANNUAL REVIEW OF MEDICINE | 2022年 / 73卷
关键词：
PLURIPOTENT STEM-CELLS; HUMAN-SPECIFIC FEATURES; IN-VIVO MODEL; KIDNEY ORGANOIDS; EPITHELIAL ORGANOIDS; HELICOBACTER-PYLORI; ROTAVIRUS INFECTION; CEREBRAL ORGANOIDS; T-CELL; REVEALS;
D O I：
10.1146/annurev-med-042320-023055
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Infectious diseases affect individual health and have widespread societal impacts. New ex vivo models are critical to understand pathogenesis, host response, and features necessary to develop preventive and therapeutic treatments. Pluripotent and tissue stem cell-derived organoids provide new tools for the study of human infections. Organoid models recapitulate many characteristics of in vivo disease and are providing new insights into human respiratory, gastrointestinal, and neuronal host-microbe interactions. Increasing culture complexity by adding the stroma, interorgan communication, and the microbiome will improve the use of organoids as models for infection. Organoid cultures provide a platform with the capability to improve human health related to infectious diseases.
引用
收藏
页码：167 / 182
页数：16
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