Overexpression of RhoA promotes the proliferation and migration of cervical cancer cells

被引：39
作者：
Liu, Xiaojun [1 ,2 ]
Chen, Dong [1 ,3 ]
Liu, Guifeng [4 ]
机构：
[1] Jilin Univ, Basic Med Coll, Dept Human Anat & Embryol, Changchun 130023, Peoples R China
[2] Jilin Univ, Dept Obstet & Gynecol, China Japan Union Hosp, Changchun 130023, Peoples R China
[3] Guangzhou Med Univ, Dept Human Anat & Embryol, Guangzhou, Guangdong, Peoples R China
[4] Jilin Univ, Dept Radiol, China Japan Union Hosp, Changchun 130023, Peoples R China
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2014年 / 78卷 / 11期
关键词：
RhoA; proliferation; migration; cervical cancer; GTPASES; EXPRESSION; METASTASIS; INVASION; KINASE; FAMILY; PROTEIN; GROWTH;
D O I：
10.1080/09168451.2014.943650
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The pro-oncogenic role of RhoA has been well identified in other cancers, but rarely in cervical cancer (CC), one of the main causes of cancer-related death in women. In the present study, we identified the overexpression of RhoA and its downstream effectors, ROCK-1 and ROCK-II, in CC specimens using western blotting. Then, we determined the effect of RhoA on the proliferation and migration of Hela cells, one of CC cell lines, by upregulating or downregulating the RhoA expression in Hela cells. We found that there was an overexpression of RhoA, ROCK-I/II in CC, which was associated with the progression of CC. And we confirmed that RhoA promoted the proliferation and migration of CC cells. In conclusion, we found a positive correlation among RhoA with the progression of CC by in vivo and in vitro evidences. A high RhoA expression in CC may predict a high metastatic potential of CC.
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收藏
页码：1895 / 1901
页数：7
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