Ligand-Free, Copper-Catalyzed Aerobic Benzylic sp3 C-H Oxygenation

被引:23
作者
Tanaka, Hirotaka [1 ]
Oisaki, Kounosuke [1 ]
Kanai, Motomu [1 ,2 ]
机构
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan
[2] Japan Sci & Technol Agcy JST, Kanai Life Sci Catalysis Project, ERATO, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan
关键词
sp(3) C-H oxygenation; copper; oxygen; ligand-free; benzylic oxidation; MOLECULAR-OXYGEN; TERMINAL OXIDANT; EFFICIENT SYNTHESIS; MILD CONDITIONS; AMINO-ACIDS; OXIDATION; BONDS; FUNCTIONALIZATION; SYSTEM; ETHERS;
D O I
10.1055/s-0036-1588969
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A ligand-free and operationally simple copper-catalyzed aerobic benzylic sp(3) C-H oxygenation was developed. The addition of tertbutyl hydroperoxide, either in a catalytic or stoichiometric amount, was key for activating stable C-H bonds under mild conditions to furnish the corresponding ketones or esters in moderate to excellent yield.
引用
收藏
页码:1576 / 1580
页数:5
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