Diabetes Mellitus as a Prognostic Factor for Locally Advanced Rectal Cancer

被引：10
|
作者：
Georgescu, Dragos Eugen [1 ,2 ]
Patrascu, Traian [1 ,2 ]
Georgescu, Teodor Florin [1 ,3 ]
Tulin, Adrian [1 ,4 ]
Mosoia, Liviu [1 ,5 ]
Bacalbasa, Nicolae [6 ,7 ]
Stiru, Ovidiu [8 ,9 ]
Georgescu, Mihai-Teodor [10 ,11 ]
机构：
[1] Carol Davila Univ Med & Pharm, Dept Gen Surg, Bucharest, Romania
[2] Dr Ion Cantacuzino Clin Hosp, Dept Gen Surg, Bucharest, Romania
[3] Bucharest Clin Emergency Hosp, Dept Gen Surg, Bucharest, Romania
[4] Clin Emergency Hosp Prof Dr Agrippa Ionescu, Dept Gen Surg, Bucharest, Romania
[5] Cent Mil Emergency Hosp Dr Carol Davila, Dept Gen Surg, Bucharest, Romania
[6] Carol Davila Univ Med & Pharm, Dept Obstet & Gynecol, Bucharest, Romania
[7] Fundeni Clin Inst, Ctr Excellence Translat Med, Dept Visceral Surg, Bucharest, Romania
[8] Emergency Inst Cardiovasc Dis Prof Dr CC Iliescu, Bucharest, Romania
[9] Carol Davila Univ Med & Pharm, Dept Cardiothorac Pathol, Bucharest, Romania
[10] Prof Dr Alex Trestioreanu Inst Oncol, Dept Radiotherapy 2, Bucharest, Romania
[11] Carol Davila Univ Med & Pharm, Dept Radiol 8, Discipline Oncol, Oncol,Haematol, Bucharest, Romania
来源：
IN VIVO | 2021年 / 35卷 / 04期
关键词：
Diabetes; rectal cancer; radiochemotherapy; COLORECTAL-CANCER; OUTCOMES; PREVENTION; MORTALITY; SURVIVAL; IMPACT;
D O I：
10.21873/invivo.12530
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background/Aim: Currently, the impact of diabetes mellitus (DM) on rectal cancer patients is complex and just partly elucidated. The purpose of this study was to investigate the impact of diabetes mellitus on rectal cancer patients focusing on tumor differentiation grade, neoadjuvant chemoradiotherapy (NACRT) response, disease-free (DFS) and overall (OS) survival. Patients and Methods: Our study's population consisted of a group of 53 patients diagnosed with locally advanced rectal cancer, who underwent NACRT, followed by radical oncological surgery. This patient population was further divided into two groups according to diabetes presence. Results: Downstaging rates, local control, DFS, and OS were lower in the DM subgroup compared to the non-DM locally advanced rectal cancer patients. Conclusion: The presence of DM at the time of diagnosis of locally advanced rectal cancer patients may be a negative predictive factor for response to neoadjuvant therapy, distant metastases, and local recurrences rates.
引用
收藏
页码：2495 / 2501
页数：7
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