Withania somnifera (L.) Dunal: Phytochemistry, structure-activity relationship, and anticancer potential

被引：36
作者：
Tewari, Devesh [1 ]
Chander, Vikas [2 ]
Dhyani, Archana [3 ]
Sahu, Sanjeev [4 ]
Gupta, Pawan [5 ]
Patni, Pooja [6 ]
Kalick, Lindsay S. [7 ]
Bishayee, Anupam [7 ,8 ]
机构：
[1] Lovely Profess Univ, Sch Pharmaceut Sci, Dept Pharmacognosy, Phagwara 144411, Punjab, India
[2] Uttarakhand Tech Univ, Dept Pharm, Dehra Dun 248007, Uttaranchal, India
[3] Grap Era Hill Univ, Sch Pharm, Dept Pharmaceut, Dehra Dun 248001, Uttaranchal, India
[4] Lovely Profess Univ, Sch Pharmaceut Sci, Dept Med Chem, Phagwara 144411, Punjab, India
[5] Ganpat Univ, Shree SK Patel Coll Pharmaceut Educ & Res, Mehsana 384012, Gujarat, India
[6] Lovely Profess Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Phagwara 144411, Punjab, India
[7] Lake Erie Coll Osteopath Med, Coll Osteopath Med, Bradenton, FL 34211 USA
[8] Lake Erie Coll Osteopath Med, Coll Osteopath Med, 5000 Lakewood Ranch Blvd, Bradenton, FL 34211 USA
来源：
PHYTOMEDICINE | 2022年 / 98卷
关键词：
Withania somnifera; Indian ginseng; Withanolides; Withaferin A; Cancer; Therapy; Molecular targets; BREAST-CANCER CELLS; WITHAFERIN-A; KAPPA-B; STEROIDAL LACTONES; MOLECULAR INSIGHTS; DOWN-REGULATION; CYCLE ARREST; APOPTOSIS; WITHANOLIDES; GROWTH;
D O I：
10.1016/j.phymed.2022.153949
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Background: Ayurveda is a highly recognized, well-documented, and well-accepted traditional medicine system. This system utilizes many natural products in various forms for therapeutic purposes. Thousands of plants mentioned in the Ayurvedic system are useful in disease mitigation and health preservation. One potential plant of the Ayurvedic system is "Ashwagandha" [Withania somnifera (L.) Dunal], commonly regarded as Indian Ginseng. It possesses various therapeutic activities, such as neuroprotective, hypoglycemic, hepatoprotective, antiarthritic, and anticancer effects. Purpose: Here we present a comprehensive insight on the anticancer effects of W. somnifera and mechanistic attributes of its bioactive phytocompounds. This review also provides updated information on the clinical studies pertaining to cancer, safety evaluation and opportunities for chemical modifications of withanolides, a group of specialized phytochemicals of W. somnifera. Methods: The present study was performed in accordance with the guidelines of the Preferred Reporting Items for Systemic Reviews and Meta-Analysis. Various scientific databases, such as PubMed, Science Direct, Scopus, Google Scholar, were explored for related studies published up to May 2021.
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页数：17
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