The Unique Properties of Uterine NK Cells

被引：146
作者：
Manaster, Irit [1 ]
Mandelboim, Ofer [1 ]
机构：
[1] Hebrew Univ Jerusalem, Hadassah Med Sch, IMRIC, Lautenberg Ctr Gen & Tumor Immunol, IL-91010 Jerusalem, Israel
来源：
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2010年 / 63卷 / 06期
基金：
以色列科学基金会;
关键词：
Decidual NK cells; endometrial NK cells; pregnancy; NATURAL-KILLER-CELLS; ENDOMETRIAL GRANULATED LYMPHOCYTES; ENDOTHELIAL GROWTH-FACTOR; MENSTRUAL-CYCLE; CYTOTOXIC ACTIVITY; GAMMA PRODUCTION; METRIAL GLAND; EXPRESSION; RECEPTOR; SUBSET;
D O I：
10.1111/j.1600-0897.2009.00794.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P>Natural killer (NK) cells are lymphocytes of the innate immunity system that are able to kill various hazardous pathogens and tumors. However, it is now widely accepted that NK cells also possess non-destructive functions, as has been demonstrated for uterine NK cells. Here, we review the unique properties of the NK cells in the uterine mucosa, prior to and during pregnancy. We discuss the phenotype and function of mouse and human endometrial and decidual NK cells and suggest that the major function of decidual NK cells is to assist in fetal development. We further discuss the origin of decidual NK cells and suggest several possibilities that might explain their accumulation in the decidua during pregnancy.
引用
收藏
页码：434 / 444
页数：11
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