The Unique Properties of Uterine NK Cells

被引：146

作者：

Manaster, Irit ^{[1
]}

Mandelboim, Ofer ^{[1
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, IMRIC, Lautenberg Ctr Gen & Tumor Immunol, IL-91010 Jerusalem, Israel

来源：

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2010年 / 63卷 / 06期

基金：

以色列科学基金会;

关键词：

Decidual NK cells; endometrial NK cells; pregnancy; NATURAL-KILLER-CELLS; ENDOMETRIAL GRANULATED LYMPHOCYTES; ENDOTHELIAL GROWTH-FACTOR; MENSTRUAL-CYCLE; CYTOTOXIC ACTIVITY; GAMMA PRODUCTION; METRIAL GLAND; EXPRESSION; RECEPTOR; SUBSET;

D O I：

10.1111/j.1600-0897.2009.00794.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

P>Natural killer (NK) cells are lymphocytes of the innate immunity system that are able to kill various hazardous pathogens and tumors. However, it is now widely accepted that NK cells also possess non-destructive functions, as has been demonstrated for uterine NK cells. Here, we review the unique properties of the NK cells in the uterine mucosa, prior to and during pregnancy. We discuss the phenotype and function of mouse and human endometrial and decidual NK cells and suggest that the major function of decidual NK cells is to assist in fetal development. We further discuss the origin of decidual NK cells and suggest several possibilities that might explain their accumulation in the decidua during pregnancy.

引用

页码：434 / 444

页数：11

共 50 条

[1] PIBF positive uterine NK cells in the mouse decidua
Bogdan, Agnes
Berta, Gergely
Szekeres-Bartho, Julia
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2017, 119 : 38 - 43
[2] Transcriptomic analysis of vitamin D responses in uterine and peripheral NK cells
Tamblyn, J. A.
Jeffery, L. E.
Susarla, R.
Lissauer, D. M.
Coort, S. L.
Garcia, A. Munoz
Knoblich, K.
Fletcher, A. L.
Bulmer, J. N.
Kilby, M. D.
Hewison, M.
REPRODUCTION, 2019, 158 (02) : 211 - 221
[3] Unique characteristics of NK cells throughout the human female reproductive tract
Mselle, Teddy F.
Meadows, Sarah K.
Eriksson, Mikael
Smith, Jennifer M.
Shen, Lilian
Wira, Charles R.
Sentman, Charles L.
CLINICAL IMMUNOLOGY, 2007, 124 (01) : 69 - 76
[4] CD200S-positive granulated lymphoid cells in endometrium appear to be CD56-positive uterine NK cells
Clark, David A.
Reihani, Amir
Arredondo, Jorge L.
Ask, Kjetil
Foster, Warren G.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2022, 150
[5] DC within the pregnant mouse uterus influence growth and functional properties of uterine NK cells
Karsten, Christian M.
Behrends, Jochen
Wagner, Arnika K.
Fuchs, Franca
Figge, Julia
Schmudde, Inken
Hellberg, Lars
Kruse, Andrea
EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (08) : 2203 - 2214
[6] Human decidual NK cells: Unique phenotype and functional properties - A review
Tabiasco, J.
Rabot, M.
Aguerre-Girr, M.
El Costa, H.
Berrebi, A.
Parant, O.
Laskarin, G.
Juretic, K.
Bensussan, A.
Rukavina, D.
Le Bouteiller, P.
PLACENTA, 2006, 27 : S34 - S39
[7] Salivary Gland NK Cells Are Phenotypically and Functionally Unique
Tessmer, Marlowe S.
Reilly, Emma C.
Brossay, Laurent
PLOS PATHOGENS, 2011, 7 (01)
[8] Human Uterine NK Cells Interact with Uterine Macrophages via NKG2D upon Stimulation with PAMPs
Basu, Satarupa
Eriksson, Mikael
Pioli, Patricia A.
Conejo-Garcia, Jose
Mselle, Teddy F.
Yamamoto, Satoshi
Wira, Charles R.
Sentman, Charles L.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2009, 61 (01) : 52 - 61
[9] Uterine NK cells and macrophages in pregnancy
Faas, Marijke M.
de Vos, Paul
PLACENTA, 2017, 56 : 44 - 52
[10] Maternal obesity drives functional alterations in uterine NK cells
Perdu, Sofie
Castellana, Barbara
Kim, Yoona
Chan, Kathy
DeLuca, Lauren
Beristain, Alexander G.
JCI INSIGHT, 2016, 1 (11)

← 1 2 3 4 5 →