A new benzophenone with biological activities from metabolites of butyrolactone I in rat faeces

被引：5

作者：

Liu, Bing ^{[1
,2
]}

Chen, Ning ^{[1
,3
]}

Xu, Ying ^{[4
]}

Zhang, Jia-Wei ^{[1
]}

Sun, Yuan ^{[1
,2
]}

Zhao, Li-Zhu ^{[4
]}

Ji, Yu-bin ^{[1
,4
]}

机构：

[1] Harbin Univ Commerce, Pharmaceut Engn Technol Res Ctr, Harbin, Heilongjiang, Peoples R China

[2] Harbin Univ Commerce, Postdoctoral Ctr Chinese Pharm, Harbin, Heilongjiang, Peoples R China

[3] Harbin Univ Commerce, Inst Pharmacol, Postdoctoral Workstn, Harbin, Heilongjiang, Peoples R China

[4] Natl Ctr Anticanc Nat Med Engn, Harbin, Heilongjiang, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 15期

关键词：

Benzophenone; butyrolactone I; rat metabolite; ASPERGILLUS-TERREUS; IDENTIFICATION; DERIVATIVES;

D O I：

10.1080/14786419.2019.1680668

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Butyrolactone I, one of the major secondary metabolites of fungus Aspergillus terreus, is a selective cdc2 kinase inhibitor. In the present study, the metabolism of butyrolactone I in male Wistar rats was investigated by characterising metabolites excreted into faeces. Following an oral dose of 40 mg/kg butyrolactone I, two phase I metabolites were isolated from the faeces of rat. The new structure was identified on the spectroscopic data analysis. The new compound V1 and known compound V2 were tested for their cytotoxicity, antimicrobial and antioxidant activity. V1 and V2 showed significant free radical scavenging ability. V2 also showed strong inhibitory activity against Staphylococcus aureus.

引用

页码：2489 / 2497

页数：9

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