The effect of tonsillectomy on John Cunningham virus serological status in multiple sclerosis patients: A retrospective case-control study

被引：0

作者：

Avila, Mirla ^{[1
]}

Okai, Annette ^{[2
]}

Thakolwiboon, Smathorn ^{[1
]}

O'Bryan, Collin ^{[4
,5
]}

Reddy Gopireddy, Murali Mohan ^{[3
]}

Gorantla, Sasikanth ^{[4
,5
]}

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Dept Neurol, 3601 4th St STOP 8321, Lubbock, TX 79430 USA

[2] Baylor Univ, Med Ctr, Baylor Scott & White Multiple Sclerosis Treatment, Dallas, TX USA

[3] Evidencian Res Associates, Bangalore, Karnataka, India

[4] OSF HealthCare Illinois Neurol Inst, Peoria, IL USA

[5] Univ Illinois, Coll Med, Peoria, IL 61656 USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2021年 / 27卷 / 08期

关键词：

John Cunningham virus; anti-JCV antibody index; progressive multifocal leukoencephalopathy; multiple sclerosis; tonsillectomy; PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY;

D O I：

10.1177/1352458520971822

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Tonsils are believed to be the initial site of the John Cunningham virus (JCV) infection. The long-term effect of childhood tonsillectomy on JCV status in multiple sclerosis (MS) patients has not been investigated. In this retrospective case-control study, we analyzed data of 144 JCV seropositive cases and 82 JCV seronegative controls from three outpatient MS clinics in the United States. Early tonsillectomy (before the age of 8) was reported among 8 (5.56%) JCV seropositive subjects and 19 (23.17%) controls. Early tonsillectomy was associated with JCV negative status (adjusted odds ratio = 5.39, 95% confidence interval = 2.13-13.62, p < 0.001) independent of age and gender.

引用

页码：1297 / 1300

页数：4

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