Pemetrexed Plus Platinum for Patients With Advanced Non-small Cell Lung Cancer and Interstitial Lung Disease

被引：11

作者：

Fujita, Tetsuo ^{[1
]}

Kuroki, Tsuguko ^{[1
]}

Hayama, Nami ^{[1
]}

Shiraishi, Yuka ^{[1
]}

Amano, Hiroyuki ^{[1
]}

Nakamura, Makoto ^{[1
]}

Hirano, Satoshi ^{[2
]}

Tabeta, Hiroshi ^{[1
]}

Nakamura, Sukeyuki ^{[1
]}

机构：

[1] Funabashi Municipal Med Ctr, Dept Respirol, 1-21-1 Kanasugi, Kanasugi, Chiba 2738588, Japan

[2] Funabashi Municipal Med Ctr, Dept Med Oncol, Kanasugi, Japan

来源：

IN VIVO | 2019年 / 33卷 / 06期

关键词：

Nonsquamous non-small-cell lung cancer; interstitial lung disease; pemetrexed; platinum; PHASE-III; CHEMOTHERAPY; CARBOPLATIN; PACLITAXEL; EFFICACY; SAFETY; BEVACIZUMAB; GEMCITABINE; COMBINATION; CISPLATIN;

D O I：

10.21873/invivo.11704

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: Pemetrexed plus platinum followed by pemetrexed maintenance has been one of the standard first-line treatments in advanced nonsquamous non-small cell lung cancer (NSCLC), but little is known regarding its safety and efficacy for patients with interstitial lung disease (ILD). Patients and Methods: The medical records of 24 patients with advanced nonsquamous NSCLC and preexisting ILD who received pemetrexed and platinum doublet therapy with and without pemetrexed maintenance in the first-line setting between December 2009 and June 2016, were retrospectively reviewed. Results: The median progression-free survival time was 4.7 months, and the median overall survival time was 9.5 months. Of the 24 patients analyzed, six received pemetrexed maintenance. Acute exacerbation of ILD (AE-ILD) occurred in five (20.8 %) of 24 patients, including two fatal cases. Conclusion: The treatment with pemetrexed plus platinum has a high risk of AE-ILD in patients with advanced nonsquamous NSCLC and preexisting ILD.

引用

页码：2059 / 2064

页数：6

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