Bacterial cellulose/poly vinyl alcohol based wound dressings with sustained antibiotic delivery

被引：24

作者：

Tamahkar, Emel ^{[1
]}

机构：

[1] Bursa Tech Univ, Dept Bioengn, Bursa, Turkey

来源：

CHEMICAL PAPERS | 2021年 / 75卷 / 08期

关键词：

Bacterial cellulose nanofibers; Poly vinyl alcohol; Wound dressing; Antibiotic delivery; NANOCOMPOSITE; COMPOSITES; MEMBRANES; HYDROGELS;

D O I：

10.1007/s11696-021-01631-w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The current work was aimed to prepare bacterial cellulose/poly vinyl alcohol (BC/PVA) wound dressings loaded with antibiotic which were prepared via freeze-thawing. The swelling ratio of BC/PVA hydrogels was in the range of 188-240%. The water loss percentage of BC was improved with the addition of PVA. 30% of the cumulative ampicillin delivery from BC/PVA hydrogels was achieved during 120 h suggesting significant role of PVA incorporation since 50% of ampicillin was released from BC after 24 h. BC/PVA hydrogels showed great antibacterial activity against E.coli and S. aureus. The results revealed that BC/PVA hydrogels presented great potential as wound dressings with high swelling ratio, low water loss percentage and slow antibiotic release properties.

引用

页码：3979 / 3987

页数：9

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