Synthetic Methods of Disulfide Bonds Applied in Drug Delivery Systems

被引：15
作者：
Wang, Kaiming [1 ]
Liu, Na [1 ]
Zhang, Pei [1 ]
Guo, Yuanyuan [1 ]
Zhang, Yongchun [1 ,2 ]
Zhao, Zhongxi [1 ,3 ]
Luan, Yuxia [1 ]
Li, Shanzhong [3 ]
Cai, Jianhua [3 ]
Cao, Jimin [3 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, 44 West Wenhua Rd, Jinan 250012, Shandong, Peoples R China
[2] Qilu Univ Technol, Sch Chem & Pharmaceut Engn, Daxue Rd,Western Univ Sci Pk, Jinan 250353, Shandong, Peoples R China
[3] Jiangsu Shengshi Kangde Biotech Corp, Lianyungang 222006, Jiangsu, Peoples R China
来源：
CURRENT ORGANIC CHEMISTRY | 2016年 / 20卷 / 14期
关键词：
Disulfane synthesis; disulfide bonds; drug delivery systems; carrier; prodrug; MESOPOROUS SILICA NANOPARTICLES; S-S BOND; POLY(ETHYLENE GLYCOL); IN-VITRO; PREACTIVATED THIOMERS; PEG; PACLITAXEL; POLYMERS; MICELLES; THERAPY;
D O I：
10.2174/1385272820666151207194002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Disulfide bond plays an important role in various fields, for example, biochemical processes, industrial and pharmaceutical chemistry, bioconjugates, peptidomimetics and self-assembled monolayers (SAMs) etc. In the past decades, drug delivery systems (DDS) have been widely investigated, and disulfide-based oxidation-reduction responsive DDS is the most promising one. Disulfide bonds have no physiological toxicity and remain stable in human body, and can be broken into a reduced form of glutathione (GSH) via the thiol-disulfide exchange reaction. Moreover, the GSH level in tumor tissues has been known to be at least 4-fold higher than that in normal tissues. Therefore, this specific redox potential in cells stimulates people to design oxidation-reduction responsive DDS for specifically releasing drugs in tumor cells and develop the new methods for the preparation of organic disulfanes. The present review has attempted to comprehensively summarize recent advances on the synthetic methods of disulfide bond in drug delivery systems.
引用
收藏
页码：1477 / 1489
页数：13
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