Dominant predictors of early post-transplant outcomes based on the Korean Organ Transplantation Registry (KOTRY)

被引：3

作者：

Jeong, Jong Cheol ^{[1
]}

Koo, Tai Yeon ^{[2
]}

Ro, Han ^{[3
]}

Lee, Dong Ryeol ^{[4
]}

Lee, Dong Won ^{[5
]}

Oh, Jieun ^{[6
]}

Kim, Jayoun ^{[7
]}

Chae, Dong-Wan ^{[8
]}

Kim, Young Hoon ^{[9
]}

Huh, Kyu Ha ^{[10
]}

Park, Jae Berm ^{[11
]}

Kim, Yeong Hoon ^{[12
]}

Han, Seungyeup ^{[13
]}

Choi, Soo Jin Na ^{[14
]}

Lee, Sik ^{[15
]}

Min, Sang-Il ^{[16
]}

Ha, Jongwon ^{[16
,17
]}

Kim, Myoung Soo ^{[10
]}

Ahn, Curie ^{[8
,18
]}

Yang, Jaeseok ^{[19
]}

机构：

[1] Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea

[2] Seongnam Citizens Med Ctr, Dept Nephrol, Seongnam, South Korea

[3] Gachon Univ, Dept Internal Med, Gil Med Ctr, Coll Med, Inchon, South Korea

[4] Maryknoll Med Ctr, Div Nephrol, Med, Busan, South Korea

[5] Pusan Natl Univ, Div Nephrol, Dept Internal Med, Sch Med, Busan, South Korea

[6] Hallym Univ, Kangdong Sacred Heart Hosp, Dept Internal Med, Coll Med, Seoul, South Korea

[7] Seoul Natl Univ, Coll Med, Med Res Collaborating Ctr, Seoul Natl Univ Hosp, Seoul, South Korea

[8] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul, South Korea

[9] Univ Ulsan, Dept Surg, Asan Med Ctr, Coll Med, Seoul, South Korea

[10] Yonsei Univ, Dept Surg, Coll Med, Seoul, South Korea

[11] Sungkyunkwan Univ, Sch Med, Dept Surg, Samsung Med Ctr, Seoul, South Korea

[12] Inje Univ, Dept Internal Med, Busan Paik Hosp, Busan, South Korea

[13] Keimyung Univ, Dept Internal Med, Sch Med, Daegu, South Korea

[14] Chonnam Natl Univ, Dept Surg, Sch Med, Gwangju, South Korea

[15] Jeonbuk Natl Univ, Dept Internal Med, Sch Med, Jeonju, South Korea

[16] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Surg, Coll Med, Seoul, South Korea

[17] Seoul Natl Univ, Med Res Ctr, Transplantat Res Inst, Coll Med, Seoul, South Korea

[18] Korean Organ Transplantat Registry Fdn, 3rd Floor,Myeongryun Gil 22, Seoul, South Korea

[19] Yonsei Univ, Coll Med, Lab Transplantat Immunol, Div Nephrol,Dept Internal Med,Severance Hosp, Room 336,3rd Floor,50 Yonsei Ro, Seoul 03722, South Korea

来源：

SCIENTIFIC REPORTS | 2022年 / 12卷 / 01期

关键词：

KIDNEY-TRANSPLANTATION; VARIABLE SELECTION; IMMUNE-RESPONSE; SCORING SYSTEM; VALIDATION; ALLOCATION; RECIPIENTS; SURVIVAL; RISK;

D O I：

10.1038/s41598-022-12302-5

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Data for Asian kidney transplants are very limited. We investigated the relative importance of prognostic markers in Asian kidney transplants by using Korean Organ Transplantation Registry (KOTRY) cohort. Prediction models were developed by data-driven variable selection approach. The relative importance of the selected predictors was measured by dominance analysis. A total of 4854 kidney transplant donor-recipient pairs were analyzed. Overall patient survival rates were 99.8%, 98.8%, and 91.8% at 1, 3, and 5 years, respectively. Death-censored graft survival rates were 98.4%, 97.0%, and 95.8% at 1, 3, and 5 years. Biopsy-proven acute rejection free survival rates were 90.1%, 87.4%, and 87.03% at 1, 3, and 5 years. The top 3 dominant predictors for recipient mortality within 1 year were recipient cardiovascular disease history, deceased donor, and recipient age. The dominant predictors for death-censored graft loss within 1 year were acute rejection, deceased donor, and desensitization. The dominant predictors to acute rejection within 1 year were donor age, HLA mismatched numbers, and desensitization. We presented clinical characteristics of patients enrolled in KOTRY during the last 5 years and investigated dominant predictors for early post-transplant outcomes, which would be useful for clinical decision-making based on quantitative measures.

引用

页数：13

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