Human copper homeostasis: a network of interconnected pathways

被引：398

作者：

Lutsenko, Svetlana ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Physiol, Baltimore, MD 21205 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2010年 / 14卷 / 02期

关键词：

METAL-BINDING DOMAINS; TRANSPORTER HCTR1; CELLULAR COPPER; LATE ENDOSOMES; ATPASE ATP7B; WILD-TYPE; EXPRESSION; MENKES; LOCALIZATION; METABOLISM;

D O I：

10.1016/j.cbpa.2010.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Copper plays an essential role in normal human physiology. Copper misbalance affects heart development, CNS and liver function, influences lipid metabolism, inflammation, and resistance to chemotherapeutic drugs. Recent studies yielded new information on the structure, function, and regulation of human copper transporters, uncovered unanticipated functions for copper chaperones, and established connections between copper homeostasis and other metabolic pathways. It has become apparent that the copper trafficking machinery is regulated at several levels and that the cross-talk between cell compartments contributes to the intracellular copper balance. The human copper regulon is emerging.

引用

页码：211 / 217

页数：7

共 61 条

[1]

ARREAONDO M, 2009, BIOL TRACE ELEM RES

[2] Mitochondrial copper(I) transfer from Cox17 to Sco1 is coupled to electron transfer [J].

Banci, Lucia ;

Bertini, Ivano ;

Ciofi-Baffoni, Simone ;

Hadjiloi, Theodoros ;

Martinelli, Manuele ;

Palumaa, Peep .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (19) :6803-6808

[3] The Binding Mode of ATP Revealed by the Solution Structure of the N-domain of Human ATP7A [J].

Banci, Lucia ;

Bertini, Ivano ;

Cantini, Francesca ;

Inagaki, Sayaka ;

Migliardi, Manuele ;

Rosato, Antonio .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (04) :2537-2544

[4] Cell-Specific Trafficking Suggests a new role for Renal ATP7B in the Intracellular Copper Storage [J].

Barnes, Natalie ;

Bartee, Mee Y. ;

Braiterman, Lita ;

Gupta, Arnab ;

Ustiyan, Vladimir ;

Zuzel, Vesna ;

Kaplan, Jack H. ;

Hubbard, Ann L. ;

Lutsenko, Svetlana .

TRAFFIC, 2009, 10 (06) :767-779

[5] Structural organization of human Cu-transporting ATPases: learning from building blocks [J].

Barry, Amanda N. ;

Shinde, Ujwal ;

Lutsenko, Svetlana .

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2010, 15 (01) :47-59

[6] The Loop Connecting Metal-Binding Domains 3 and 4 of ATP7B Is a Target of a Kinase-Mediated Phosphorylation [J].

Bartee, Mee Y. ;

Ralle, Martina ;

Lutsenko, Svetlana .

BIOCHEMISTRY, 2009, 48 (24) :5573-5581

[7] Regulation of Prion Gene Expression by Transcription Factors SP1 and Metal Transcription Factor-1 [J].

Bellingham, Shayne A. ;

Coleman, Louise A. ;

Masters, Colin L. ;

Camakaris, James ;

Hill, Andrew F. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (02) :1291-1301

[8] Ctr2 is partially localized to the plasma membrane and stimulates copper uptake in COS-7 cells [J].

Bertinato, Jesse ;

Swist, Eleonora ;

Plouffe, Louise J. ;

Brooks, Stephen P. J. ;

L'Abbe, Mary R. .

BIOCHEMICAL JOURNAL, 2008, 409 :731-740

[9] Crystal Structures of Cisplatin Bound to a Human Copper Chaperone [J].

Boal, Amie K. ;

Rosenzweig, Amy C. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (40) :14196-+

[10] Structural Biology of Copper Trafficking [J].

Boal, Amie K. ;

Rosenzweig, Amy C. .

CHEMICAL REVIEWS, 2009, 109 (10) :4760-4779

← 1 2 3 4 5 6 7 →