Psoriasis and Systemic Inflammatory Disorders

被引：60

作者：

Tashiro, Tomoko ^{[1
]}

Sawada, Yu ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Dept Dermatol, Kitakyushu, Fukuoka 8078555, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 08期

关键词：

psoriasis; IL-17; TNF-alpha; organs; inflammation; FATTY LIVER-DISEASE; TH17; CELLS; T-CELLS; MYOCARDIAL-INFARCTION; INCREASED RISK; CHRONIC RHINOSINUSITIS; VASCULAR INFLAMMATION; RHEUMATOID-ARTHRITIS; ATRIAL-FIBRILLATION; GUT INFLAMMATION;

D O I：

10.3390/ijms23084457

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psoriasis is a representative inflammatory skin disease occupied by large surface involvement. As inflammatory cells and cytokines can systemically circulate in various organs, it has been speculated that psoriatic skin inflammation influences the systemic dysfunction of various organs. Recent updates of clinical studies and experimental studies showed the important interaction of psoriasis to systemic inflammatory diseases. Furthermore, the importance of systemic therapy in severe psoriasis is also highlighted to prevent the development of systemic inflammatory diseases. In this review, we introduced representative systemic inflammatory diseases associated with psoriasis and the detailed molecular mechanisms.

引用

页数：15

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