Halogens halt aromatic group migration in Baeyer-Villiger oxidation

被引：7

作者：

Adejare, A ^{[1
]}

Shen, J

Ogunbadeniyi, AM

机构：

[1] Idaho State Univ, Coll Pharm, Dept Pharmaceut Sci, Pocatello, ID 83209 USA

[2] Univ Missouri, Sch Pharm, Div Pharmaceut Sci, Kansas City, MO 64110 USA

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2000年 / 105卷 / 01期

基金：

美国国家卫生研究院;

关键词：

fluorobenzaldehyde; fluorocarboxylic acid; Baeyer-Villiger oxidation mechanism;

D O I：

10.1016/S0022-1139(00)00296-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Oxidation of a dihalogenated benzaldehyde under Baeyer-Villiger conditions led to the aromatic carboxylic acid as opposed to the desired phenol. Fluorine was located at the para-position of the benzaldehyde, halting migration of the aryl group and thus resulting in the carboxylic acid product. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：107 / 109

页数：3