Na-promoted aerobic oxidation of alcohols to ketones

被引：16

作者：

Zhou, Li-Hong ^{[1
,2
]}

Yu, Xiao-Qi ^{[1
]}

Pu, Lin ^{[2
]}

机构：

[1] Sichuan Univ, Minist Educ, Dept Chem, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

[2] Univ Virginia, Dept Chem, Charlottesville, VA USA

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 03期

基金：

美国国家科学基金会;

关键词：

Na; Oxidation; Alcohols; Ketones; Aerobic; Anaerobic; PALLADIUM-CATALYZED OXIDATION; OXIDANT-FREE DEHYDROGENATION; HETEROGENEOUS CATALYST; EFFICIENT; ALDEHYDES; COMPLEXES; HYDROGEN; CREATION; SURFACE; SYSTEM;

D O I：

10.1016/j.tetlet.2009.11.079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aerobic oxidation of a number of diaryl and arylalkyl carbinols to ketones was promoted by Na in THF at room temperature with up to 99% yield. This new oxidation method is also selective with good efficiency for the oxidation of benzylic secondary alcohols but not for a primary alcohol or nonbenzylic secondary alcohols. Under nitrogen, a catalytic amount of Ni or transition metal halides such as COCl3, FeCl3, and NiCl3 in combination with Na was also found to conduct a dehydrogenation of a secondary alcohol to the corresponding ketone in high yield at room temperature. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：475 / 477

页数：3

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