Congenital lung lesions - underlying molecular mechanisms

Congenital lung lesions comprise a broad spectrum of rate but clinically significant developmental abnormalities. including congenital cystic adenomatoid malformation. bronchopulmonary sequestrations, congenital lobar emphysema, and bronchogenic cysts, which are commonly surgically treated Although the terms congenital cystic adenomatoid malformation. bronchopulmonary sequestrations, congenital lobar emphysema, and bronchogenic cysts are entrenched in clinical usage and comfortably correspond to rigid pathologic definitions, there is a considerable overlap in the findings. the controversy about lesion nomenclature and classification. it is widely accepted that congenital lung lesions result-flout perturbations in lung and airway embryogenesis. It is generally accepted that both place (level in the tracheobronchial nee) and timing (gestational age) of the embryologic insult correlates with the type of lesion and histopathology that is manifested The objective of this review is to briefly review normal lung development and to analyze the known molecular mechanisms underlying those diseases (C) 2010 Elsevier Inc All rights reserved