Evaluation of the Gradient Concentration Strip Method for Antifungal Susceptibility Testing of Isavuconazole and Comparators for Mucorales Species

被引：7
作者：
Vidal, Pauline [1 ,2 ]
Schwarz, Patrick [3 ,4 ]
Dannaoui, Eric [1 ,5 ,6 ]
机构：
[1] Hop Europeen Georges Pompidou, Serv Microbiol, Unite Parasitol Mycol, Paris, France
[2] Univ Paris Sud, Fac Pharm, Chatenay Malabry, France
[3] Univ Hosp Marburg, Dept Internal Med Resp & Crit Care Med, Marburg, Germany
[4] Philipps Univ Marburg, Ctr Invas Mycoses & Antifungals, Marburg, Germany
[5] Univ Paris 05, Fac Med, Paris, France
[6] Paris Est Creteil Univ, Ecole Natl Vet Alfort, Dynamyc Res Grp, EA 7380, Creteil, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 10期
关键词：
EUCAST; Etest; Mucorales; antifungal agents; antifungal susceptibility testing; filamentous fungi; BROTH MICRODILUTION; AMPHOTERICIN-B; ASPERGILLUS; MUCORMYCOSIS; POSACONAZOLE; ETEST; ITRACONAZOLE; VORICONAZOLE; CANDIDA; FUNGI;
D O I：
10.1128/AAC.00838-19
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
MIC values for amphotericin B and three azoles determined by the EU-CAST reference technique and by gradient concentration strips were compared for 30 Mucorales isolates belonging to clinically important species. Essential agreement (EA) within +/- 2 dilution steps at 24 hours between the techniques was 83.3% for isavuconazole. EAs for itraconazole, amphotericin B, and posaconazole were 86.7%, 73.3%, and 56.7%, respectively. A good agreement was obtained between visual and spectrophotometric readings for EUCAST.
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页数：6
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