Cajal bodies and snRNPs - friends with benefits

被引：52

作者：

Stanek, David ^{[1
]}

机构：

[1] Czech Acad Sci, Inst Mol Genet, Videnska 1083, Prague 14220, Czech Republic

来源：

RNA BIOLOGY | 2017年 / 14卷 / 06期

关键词：

SPINAL MUSCULAR-ATROPHY; SMALL NUCLEAR-RNA; U4/U6.U5; TRI-SNRNP; XENOPUS-LAEVIS OOCYTES; U6 SPLICEOSOMAL RNA; COILED BODIES; SMN COMPLEX; U1; SNRNP; U2; IN-VIVO;

D O I：

10.1080/15476286.2016.1231359

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spliceosomal snRNPs are complex particles that proceed through a fascinating maturation pathway. Several steps of this pathway are closely linked to nuclear non-membrane structures called Cajal bodies. In this review, I summarize the last 20 y of research in this field. I primarily focus on snRNP biogenesis, specifically on the steps that involve Cajal bodies. I also evaluate the contribution of the Cajal body in snRNP quality control and discuss the role of snRNPs in Cajal body formation.

引用

页码：671 / 679

页数：9

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