Interaction of granulocyte colony-stimulating factor and high doses of liposomal amphotericin B in the treatment of systemic murine scedosporiosis

被引：40

作者：

Ortoneda, M ^{[1
]}

Capilla, J ^{[1
]}

Pastor, FJ ^{[1
]}

Serena, C ^{[1
]}

Guarro, J ^{[1
]}

机构：

[1] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unitat Microbiol, E-43201 Reus, Spain

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2004年 / 50卷 / 04期

关键词：

Scedosporium prolificans; liposomal amphotericin B; G-CSF;

D O I：

10.1016/j.diagmicrobio.2004.07.011

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Because human infections by Scedosporium prolificans are difficult to treat and show a very poor outcome, new therapeutic strategies are needed. Liposomal amphotericin B (LAMB) (40 mg/kg/day) increased significantly the mean survival time in immunosuppressed mice compared with a control group (22.6 vs. 8.8 days). Amphotericin B deoxycholate (1.5 mg/kg/day) and granulocyte colony-stimulating factor (G-CSF) (300 mug/kg/day) were ineffective. The combination of LAMB (40 mg/kg/day) and G-CSF (150 or 300 mug/kg/day) did not improve the results obtained with LAMB alone. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：247 / 251

页数：5

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