Melanoma Associated With Long-term Voriconazole Therapy A New Manifestation of Chronic Photosensitivity

被引:89
作者
Miller, Daniel D. [1 ]
Cowen, Edward W. [3 ]
Nguyen, Josephine C. [4 ]
McCalmont, Timothy H. [1 ,2 ]
Fox, Lindy P. [1 ]
机构
[1] Univ Calif San Francisco, Dept Dermatol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
[3] NCI, Dermatol Branch, Ctr Canc Res, NIH, Bethesda, MD USA
[4] Univ Penn, Dept Dermatol, Philadelphia, PA 19104 USA
关键词
TRIAZOLE ANTIFUNGAL AGENT; XERODERMA-PIGMENTOSUM; SKIN-CANCER; PSEUDOPORPHYRIA; ASPERGILLOSIS; PREVENTION; CHILDREN; PATIENT;
D O I
10.1001/archdermatol.2009.362
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Voriconazole is a triazole antifungal agent approved by the US Food and Drug Administration for serious fungal infections, including with Aspergillus, Fusarium, Pseudallescheria, and Scedosporium species. In initial clinical trials, approximately 2% of patients developed cutaneous reactions, including photosensitivity, cheilitis, and xerosis. Subsequent reports have implicated voriconazole as a cause of severe photosensitivity and accelerated photoaging, pseudoporphyria cutanea tarda, and aggressive squamous cell carcinoma. Observation: We report 5 melanoma in situ lesions in the setting of extreme photosensitivity associated with long-term voriconazole therapy. Conclusions: We recommend surveillance for skin cancer formation in all patients who require long-term voriconazole treatment, particularly those who manifest signs or symptoms of photosensitivity or chronic photo-damage. Further study of the mechanism underlying voriconazole photosensitivity and oncogenesis is warranted.
引用
收藏
页码:300 / 304
页数:5
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