Small Cell Lung Cancer in a 20-year-old Non-Smoking Man with Systemic Sclerosis

被引：0

作者：

Saito, Go ^{[1
,2
]}

Jinta, Torahiko ^{[1
]}

Nakaoka, Hiroshi ^{[1
]}

Kitamura, Atsushi ^{[1
]}

Yamaguchi, Kenichi ^{[3
]}

Nishimura, Naoki ^{[1
]}

机构：

[1] St Lukes Int Hosp, Div Pulm Med, Tokyo, Japan

[2] Seirei Hamamatsu Gen Hosp, Dept Pulm Med, Hamamatsu, Shizuoka, Japan

[3] St Lukes Int Hosp, Immuno Rheumatol Ctr, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2017年 / 56卷 / 12期

关键词：

small cell lung cancer; systemic sclerosis; non-smoker; 20-year-old; OF-THE-LITERATURE; NEVER-SMOKERS; SCLERODERMA; CARCINOMA; DATABASE; GENOME; ONSET;

D O I：

10.2169/internalmedicine.56.7985

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Small cell lung cancer (SCLC) is a neuroendocrine tumor, and the median age of onset is about 70 years old. A 20-year-old non-smoking man with known systemic sclerosis presented with discomfort in his left chest. Chest X-ray showed a mass shadow in the left upper zone. A transbronchial lung biopsy revealed small cell carcinoma, and imaging studies reached the diagnosis of extensive disease small cell lung cancer. He had concurrent interstitial lung disease with a non-specific interstitial pneumonia pattern and anti-Scl-70 antibodies. He died eight months after the diagnosis during fifth-line chemotherapy. We herein report the youngest case to date of SCLC with systemic sclerosis.

引用

页码：1549 / 1552

页数：4

共 24 条

[1] Trends, predictors, and impact of systemic chemotherapy in small cell lung cancer patients between 1985 and 2005 [J].

Behera, Madhusmita ;

Ragin, Camille ;

Kim, Sungjin ;

Pillai, Rathi N. ;

Chen, Zhengjia ;

Steuer, Conor E. ;

Saba, Nabil F. ;

Belani, Chandra P. ;

Khuri, Fadlo R. ;

Ramalingam, Suresh S. ;

Owonikoko, Taofeek K. .

CANCER, 2016, 122 (01) :50-60

[2] Presynaptic neuronal antigens expressed by a small cell lung carcinoma cell line [J].

Benatar, M ;

Blaes, F ;

Johnston, I ;

Wilson, K ;

Vincent, A ;

Beeson, D ;

Lang, B .

JOURNAL OF NEUROIMMUNOLOGY, 2001, 113 (01) :153-162

[3] Systemic sclerosis (scleroderma) and cancer risk: systematic review and meta-analysis of observational studies [J].

Bonifazi, Martina ;

Tramacere, Irene ;

Pomponio, Giovanni ;

Gabrielli, Barbara ;

Avvedimento, Enrico V. ;

La Vecchia, Carlo ;

Negri, Eva ;

Gabrielli, Armando .

RHEUMATOLOGY, 2013, 52 (01) :143-154

[4] Lung cancer in scleroderma: Results from an Italian rheumatologic center and review of the literature [J].

Colaci, Michele ;

Giuggioli, Dilia ;

Sebastiani, Marco ;

Manfredi, Andreina ;

Vacchi, Caterina ;

Spagnolo, Paolo ;

Cerri, Stefania ;

Luppi, Fabrizio ;

Richeldi, Luca ;

Ferri, Clodoveo .

AUTOIMMUNITY REVIEWS, 2013, 12 (03) :374-379

[5] Juvenile and young adult-onset systemic sclerosis share the same organ involvement in adulthood: data from the EUSTAR database [J].

Foeldvari, Ivan ;

Tyndall, Alan ;

Zulian, Francesco ;

Mueller-Ladner, Ulf ;

Czirjak, Laszlo ;

Denton, Chris ;

Kowal-Bielecka, Ottilia ;

Bancel, Dominique Farge ;

Matucci-Cerinic, Marco .

RHEUMATOLOGY, 2012, 51 (10) :1832-1837

[6] Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: Analysis of the surveillance, epidemiologic, and end results database [J].

Govindan, Ramaswamy ;

Page, Nathan ;

Morgensztern, Daniel ;

Read, William ;

Tierney, Ryan ;

Vlahiotis, Anna ;

Spitznagel, Edward L. ;

Piccirillo, Jay .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (28) :4539-4544

[7] Association of the Autoimmune Disease Scleroderma with an Immunologic Response to Cancer [J].

Joseph, Christine G. ;

Darrah, Erika ;

Shah, Ami A. ;

Skora, Andrew D. ;

Casciola-Rosen, Livia A. ;

Wigley, Fredrick M. ;

Boin, Francesco ;

Fava, Andrea ;

Thoburn, Chris ;

Kinde, Isaac ;

Jiao, Yuchen ;

Papadopoulos, Nickolas ;

Kinzler, Kenneth W. ;

Vogelstein, Bert ;

Rosen, Antony .

SCIENCE, 2014, 343 (6167) :152-157

[8] Small cell lung cancer associated with systemic sclerosis [J].

Kanaji, N ;

Fujita, J ;

Bandoh, S ;

Fukumoto, T ;

Ishikawa, M ;

Haba, R ;

Ishii, T ;

Kubo, A ;

Ishida, T .

INTERNAL MEDICINE, 2005, 44 (04) :315-318

[9] Early Stage Lung Cancer Detection in Systemic Sclerosis Does Not Portend Survival Benefit: A Cross Sectional Study [J].

Katzen, Jeremy B. ;

Raparia, Kirtee ;

Agrawal, Rishi ;

Patel, Jyoti D. ;

Rademaker, Alfred ;

Varga, John ;

Dematte, Jane E. .

PLOS ONE, 2015, 10 (02)

[10]

Kim CK, 2000, PEDIATR PULM, V29, P317, DOI 10.1002/(SICI)1099-0496(200004)29:4<317::AID-PPUL12>3.0.CO

← 1 2 3 →