Intramuscular inoculation of calves with an experimental Newcastle disease virus-based vector vaccine elicits neutralizing antibodies against Rift Valley fever virus

被引：53
作者：
Kortekaas, J. [1 ]
Dekker, A. [1 ]
de Boer, S. M. [1 ,2 ]
Weerdmeester, K. [1 ]
Vloet, R. P. M. [1 ]
de Wit, A. A. C. [1 ]
Peeters, B. P. H. [1 ]
Moormann, R. J. M. [1 ]
机构：
[1] Wageningen Univ Res Ctr, Cent Vet Inst, Div Virol, NL-8219 PH Lelystad, Netherlands
[2] Univ Utrecht, Fac Vet Med, Div Virol, Dept Infect Dis & Immunol, NL-3584 CL Utrecht, Netherlands
来源：
VACCINE | 2010年 / 28卷 / 11期
关键词：
Newcastle disease virus; Vaccine; Intramuscular; Rift Valley fever virus; AVIAN INFLUENZA; RESPIRATORY-TRACT; FUSION PROTEIN; FOREIGN GENE; I INTERFERON; CLONED CDNA; EXPRESSION; HUMANS; IMMUNIZATION; REPLICATION;
D O I：
10.1016/j.vaccine.2010.01.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the past decade, the use of Newcastle disease virus (NDV) as a vaccine vector for the prevention of economically important livestock diseases as well as for human diseases has been extensively explored. In this study, we have constructed a recombinant NDV vaccine virus, named NDFL-Gn, that produces the Rift Valley fever virus (RVFV) Gn glycoprotein. Calves were immunized via either the intranasal route or the intramuscular route. Delivery via the intranasal route elicited no detectable antibody responses, whereas delivery via the intramuscular route elicited antibodies against both NDV and the Gn protein. The RVFV-neutralizing activity of the antisera from intramuscularly vaccinated calves was demonstrated, suggesting that NDV is a promising vaccine vector for the prevention of RVF in calves. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2271 / 2276
页数：6
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