ROR1: an orphan becomes apparent

被引:50
作者
Kipps, Thomas J. [1 ]
机构
[1] Univ Calif San Diego, Dept Med, Ctr Novel Therapeut, Moores Canc Ctr, La Jolla, CA 92093 USA
基金
美国国家卫生研究院;
关键词
CHRONIC LYMPHOCYTIC-LEUKEMIA; RECEPTOR TYROSINE KINASE; WNT5A INDUCES ROR1; ANTIGEN ROR1; SKELETAL ABNORMALITIES; DOWN-REGULATION; B-CELLS; EXPRESSION; CANCER; FAMILY;
D O I
10.1182/blood.2021014760
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Since its initial identification in 1992 as a possible class 1 cellsurface receptor without a known parent ligand, receptor tyrosine kinase-like orphan receptor 1 (ROR1) has stimulated research, which has made apparent its significance in embryonic development and cancer. Chronic lymphocytic leukemia (CLL) was the first malignancy found to have distinctive expression of ROR1, which can help distinguish leukemia cells from most noncancer cells. Aside from its potential utility as a diagnostic marker or target for therapy, ROR1 also factors in the pathophysiology of CLL. This review is a report of the studies that have elucidated the expression, biology, and evolving strategies for targeting ROR1 that hold promise for improving the therapy of patients with CLL or other ROR1-expressing malignancies.
引用
收藏
页码:1583 / 1591
页数:9
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