Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands

被引：72
|
作者：
Ingoglia, Bryan T. [1 ]
Buchwald, Stephen L. [1 ]
机构：
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 11期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
PD-CATALYZED FLUORINATION; PALLADACYCLE PRECATALYST; PALLADIUM PRECATALYSTS; ACID-ESTERS; ARYL; HALIDES; ARYLATION; SECONDARY; DESIGN; TEMPERATURE;
D O I：
10.1021/acs.orglett.7b01082
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this report, we describe the application of palladium-based oxidative addition complexes (OACs) as effective precatalysts for C-N, C-O, and C-F cross-coupling reactions with a variety of (hetero)arenes. These complexes offer a convenient alternative to previously developed classes of precatalysts, particularly in the case of the bulkiest biarylphosphine ligands, for which palladacycle-based precatalysts do not readily form. The precatalysts described herein are easily prepared and stable to long-term storage under air.
引用
收藏
页码：2853 / 2856
页数：4
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