Rift Valley fever vaccines

被引：107

作者：

Ikegami, Tetsuro ^{[1
,3
,4
]}

Makino, Shinji ^{[2
,3
,4
]}

机构：

[1] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA

[2] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[3] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA

[4] Univ Texas Med Branch, Ctr Biodef & Emerging Infect Dis, Galveston, TX 77555 USA

来源：

VACCINE | 2009年 / 27卷

关键词：

Rift Valley fever virus; MP-12; Vaccine; VIRUS-LIKE PARTICLES; EXPRESSION; IMMUNOGENICITY; MUTATIONS; GENOME; TRIAL; IDENTIFICATION; PATHOGENICITY; DETERMINANTS; IMMUNIZATION;

D O I：

10.1016/j.vaccine.2009.07.046

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Rift Valley fever virus (RVFV), which belongs to the genus Phlebovirus, family Bunyaviridae, is a negative-stranded RNA virus carrying a tripartite RNA genome. RVFV is transmitted by mosquitoes and causes large outbreaks among ruminants and humans in Africa and the Arabian Peninsula. Human patients develop an acute febrile illness, followed by a fatal hemorrhagic fever, encephalitis or ocular diseases, whereas ruminants experience abortions during outbreak. Effective vaccination of both humans and ruminants is the best approach to control Rift Valley fever. This article summarizes the development of inactivated RVFV vaccine, live attenuated vaccine, and other new generation vaccines. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：D69 / D72

页数：4

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