Vitamin C Deficiency-Induced Pulmonary Arterial Hypertension

被引：16

作者：

Gayen, Shameek K. ^{[1
]}

Abdelrahman, Abd A. ^{[2
]}

Preston, Ioana R. ^{[2
]}

Petit, Raymond D. ^{[3
]}

Hill, Nicholas S. ^{[2
]}

机构：

[1] Tufts Med Ctr, Dept Internal Med, Boston, MA 02111 USA

[2] Tufts Med Ctr, Dept Pulm Crit Care & Sleep Med, Boston, MA 02111 USA

[3] Sturdy Mem Hosp, Dept Pulm Med & Crit Care, Attleboro, MA USA

来源：

CHEST | 2020年 / 157卷 / 02期

关键词：

case report; pulmonary arterial hypertension; respiratory failure; THERAPY; IRON;

D O I：

10.1016/j.chest.2019.06.043

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

We report a case of a man in his 60s who developed pulmonary arterial hypertension (PAH) in association with profound vitamin C deficiency. Decreased availability of endothelial nitric oxide and activation of the hypoxia-inducible family of transcription factors, both consequences of vitamin C deficiency, are believed to be mechanisms contributing to the pathogenesis of the pulmonary hypertension. The PAH resolved following vitamin C supplementation. The current case highlights the importance of testing for vitamin C deficiency in patients with PAH in the proper clinical setting.

引用

页码：E21 / E23

页数：3

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