RETRACTED: Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease (Retracted Article)

被引:29
作者
Liu, Hong [1 ,2 ,3 ]
Chen, Si [4 ]
Guo, Cunju [2 ,3 ]
Tang, Wenqiang [5 ]
Liu, Wei [5 ]
Liu, Yiming [1 ]
机构
[1] Shandong Univ, Qilu Hosp, Dept Neurol, Jinan, Shandong, Peoples R China
[2] Taishan Med Col, Peoples Hosp Liaocheng, Dept Neurol, Liaocheng, Shandong, Peoples R China
[3] Liaocheng Univ, Hosp 1, Dept Neurol, Liaocheng, Shandong, Peoples R China
[4] Shandong Univ, Qilu Hosp, Dept Neurosurg, Jinan, Shandong, Peoples R China
[5] Taishan Med Coll, Peoples Hosp Liaocheng, Dept Cent Lab, Liaocheng, Shandong, Peoples R China
来源
MEDICAL SCIENCE MONITOR | 2018年 / 24卷
关键词
Mitochondrial Diseases; Parkinson Disease; Polysaccharides; OXIDATIVE STRESS; UP-REGULATION; APOPTOSIS; CELLS; DYSFUNCTION; PINK1; MICE;
D O I
10.12659/MSM.908021
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: Astragalus polysaccharides (APS) have a very good therapeutic effect in the treatment of neurodegenerative diseases and nerve injury disease. However, research on Parkinson disease (PD) treatment with APS is lacking. Material/Methods: The present study was designed to explore the effects of APS on the protection of neurons and mitochondrial in a mouse model of PD using behavioral experiments, and observations of mitochondrial structure and transmembrane potential. Results: It was shown that APS could attenuate 1-methyl-4-pheyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction (P<0.01), increase the proportion of TH-positive cells (P<0.01), reverse MPTP-induced mitochondrial structural damage, and reduce MPTP-induced high levels of reactive oxygen species (ROS) and increase MPTP-induced decrease in mitochondrial membrane potential. In addition, APS also decreased the bax/bcl2 ratio, and cytochrome-c and caspase-3 protein content (P<0.01) in substantia nigra in our mouse PD model. Conclusions: APS provided a protective effect on neurons and mitochondrial in a mouse PD model.
引用
收藏
页码:5192 / 5199
页数:8
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